Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

1999 • 726 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Multi‐faceted regulation of cell differentiation by extracellular matrix

1993 • 610 citations

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1999 • 593 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

1998 • 451 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1996 • 328 citations

Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

1990 • 313 citations

Integrin α1β1 Mediates a Unique Collagen-dependent Proliferation Pathway In Vivo

1998 • 299 citations

Effects of intercellular contact on repair of radiation damage

1972 • 287 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

1997 • 243 citations

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma

2000 • 225 citations

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1

1999 • 218 citations

Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.

1995 • 216 citations

Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors

1993 • 169 citations

Repression of p27^kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells

1996 • 168 citations

p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

1999 • 165 citations

Integrin-Mediated Drug Resistance in Multiple Myeloma

2000 • 155 citations

α5β1 Integrin Protects Intestinal Epithelial Cells from Apoptosis through a Phosphatidylinositol 3-Kinase and Protein Kinase B–dependent Pathway

2000 • 155 citations

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

1998 • 123 citations

Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β_1C

1995 • 123 citations

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis

1999 • 102 citations

Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo

1990 • 96 citations

p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells

1999 • 91 citations

Differential Sensitivity to Static Visual Cues in the Control of Postural Equilibrium in Man

1994 • 90 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 90 citations

Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells

1996 • 81 citations

Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin.

1998 • 78 citations

Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors

2000 • 78 citations

Ectopic p21WAF1 Expression Induces Differentiation-specific Cell Cycle Changes in PC12 Cells Characteristic of Nerve Growth Factor Treatment

1998 • 74 citations

β1D Integrin Inhibits Cell Cycle Progression in Normal Myoblasts and Fibroblasts

1998 • 64 citations

The role of p27kip1 in the in vitro differentiation of murine keratinocytes.

1997 • 63 citations

Expression of multiple β1 integrins on circulating monoclonal B cells in patients with multiple myeloma

1993 • 62 citations

The Novel Structural Motif Gln795–Gln802 in the Integrin β1C Cytoplasmic Domain Regulates Cell Proliferation

1995 • 57 citations

Reduced expression of p27Kip1 correlates with an early stage of cancer invasion in oral squamous cell carcinoma

2000 • 56 citations

p27kip1 acts as a downstream effector of and is coexpressed with the β1C integrin in prostatic adenocarcinoma

1999 • 55 citations

The Role of Adhesion Molecules in Multiple Myeloma

1997 • 55 citations

Integrin activation suppresses etoposide-induced DNA strand breakage in cultured murine tumor-derived endothelial cells.

1996 • 49 citations

Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl -transfected murine hematopoietic cells

1999 • 47 citations

Monoclonal antibody crosslinking of the alpha 4 or beta 1 integrin inhibits committed clonogenic hematopoietic progenitor proliferation.

1997 • 46 citations

p27 Modulates Cell Cycle Progression and Chemosensitivity in Human Malignant Glioma

1999 • 40 citations

Cyclin D3-associated Kinase Activity Is Regulated by p27^kip1in BALB/c 3T3 Cells

1998 • 35 citations

p27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer

1999 • 32 citations

Activation of beta 1 integrin fibronectin receptors on HL60 cells after granulocytic differentiation

1994 • 28 citations