Role of Members of the Wnt Gene Family in Human Hematopoiesis

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

A frizzled homolog functions in a vertebrate Wnt signaling pathway

1996 • 471 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells

1997 • 355 citations

Xwnt-11: a maternally expressed Xenopus wnt gene

1993 • 308 citations

Developmental biology of hematopoiesis

1995 • 306 citations

Differential Transformation of Mammary Epithelial Cells by Wnt Genes

1994 • 305 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Developmental biology of hematopoiesis

1995 • 268 citations

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

1991 • 243 citations

Differential transformation of mammary epithelial cells by Wnt genes.

1994 • 237 citations

Inducing factors in Xenopus early embryos

1994 • 234 citations

Localized BMP-4 Mediates Dorsal/Ventral Patterning in the Early Xenopus Embryo

1995 • 229 citations

Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro

1988 • 229 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

1988 • 213 citations

Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells

1996 • 204 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis

1996 • 195 citations

The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

1994 • 145 citations

The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

1992 • 138 citations

Interacting cytokines regulate in vitro human megakaryocytopoiesis

1989 • 130 citations

Ventral Expression of GATA-1 and GATA-2 in the Xenopus Embryo Defines Induction of Hematopoietic Mesoderm

1994 • 128 citations

Diversification of the Wnt gene family on the ancestral lineage of vertebrates.

1992 • 127 citations

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.

1992 • 109 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms

1991 • 100 citations

Constitutive and modulated cytokine expression in two permanent human bone marrow stromal cell lines.

1996 • 90 citations

Transforming growth factor β: Possible roles in the regulation of normal and leukemic hematopoietic cell growth

1989 • 82 citations

The Broad Spectrum of Cytokine Gene Expression by Myoid Cells from the Human Marrow Microenvironment

1997 • 77 citations

In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells

1993 • 76 citations

Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1 (int-1) oncogene in reconstituted mammary gland.

1992 • 58 citations

Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer ephithelium

1996 • 57 citations

The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis

1996 • 35 citations

Experimental analysis of ventral blood island hematopoiesis in Xenopus embryonic chimeras

1989 • 27 citations