Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

1998 • 2,028 citations

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

2001 • 1,028 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Requirement for Wnt3 in vertebrate axis formation

1999 • 882 citations

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

1997 • 851 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

1998 • 769 citations

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

1997 • 725 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

A new secreted protein that binds to Wnt proteins and inhibits their activites

1999 • 706 citations

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

2001 • 696 citations

Mouse Otx2 functions in the formation and patterning of rostral head.

1995 • 690 citations

Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation

1995 • 683 citations

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

1995 • 662 citations

Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

2000 • 643 citations

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

1993 • 617 citations

WNTs modulate cell fate and behavior during vertebrate development

1997 • 604 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Inhibition of Wnt activity induces heart formation from posterior mesoderm

2001 • 581 citations

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

1997 • 573 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

The organizer factors Chordin and Noggin are required for mouse forebrain development

2000 • 528 citations

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

1997 • 508 citations

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

1996 • 502 citations

Functional and structural diversity of the human Dickkopf gene family

1999 • 486 citations

Wnt antagonism initiates cardiogenesis in Xenopus laevis

2001 • 479 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

Fgf8 signalling from the AER is essential for normal limb development

2000 • 444 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud

1998 • 413 citations

Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

2000 • 396 citations

WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo

2001 • 360 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

1996 • 345 citations

The role of Pax-1 in axial skeleton development

1994 • 343 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 335 citations

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

1994 • 333 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

Role of TGFβs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod

1996 • 324 citations

Fgf8 is required for outgrowth and patterning of the limbs

2000 • 319 citations

Control of Vertebrate Limb Outgrowth by the Proximal Factor Meis2 and Distal Antagonism of BMPs by Gremlin

1999 • 317 citations

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 314 citations

Anterior patterning in mouse

1998 • 287 citations

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke’s pouch of the mouse embryo

1996 • 286 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome

2000 • 261 citations

Roles for Msx and Dlx homeoproteins in vertebrate development

2000 • 250 citations

MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation

1996 • 237 citations

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus

1997 • 224 citations

Head in the WNT: the molecular nature of Spemann’s head organizer

1999 • 202 citations

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

1997 • 202 citations

Dickkopf genes are co-ordinately expressed in mesodermal lineages

1999 • 194 citations

Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation

2000 • 188 citations

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling

2000 • 186 citations

Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse

1999 • 163 citations

Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast

2000 • 146 citations

Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm

1997 • 145 citations

Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo

2001 • 142 citations

The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning

2000 • 142 citations

Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo

1999 • 138 citations

Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.

1991 • 128 citations

Structurally Related Receptors and Antagonists Compete for Secreted Wnt Ligands

1997 • 127 citations

Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate

2000 • 120 citations

Skeletal abnormalities in doubly heterozygousBmp4 andBmp7 mice

1998 • 120 citations

The Homeobox Gene Hesx1 Is Required in the Anterior Neural Ectoderm for Normal Forebrain Formation

2000 • 108 citations

Morphological Diversity of the Avian Foot Is Related with the Pattern ofmsxGene Expression in the Developing Autopod

1998 • 100 citations

The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain

2000 • 95 citations

Spatially distinct head and heart inducers within the Xenopus organizer region

1999 • 90 citations

Shaping limbs by apoptosis.

1998 • 86 citations

The Spemann Organizer ofXenopusIs Patterned along Its Anteroposterior Axis at the Earliest Gastrula Stage

1997 • 84 citations

Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos

1999 • 84 citations

Shaping limbs by apoptosis>

1998 • 78 citations

Positive and negative signals modulate formation of the Xenopus cement gland

1996 • 69 citations

Gene expression profiles in normal and Otx2 ^−/− early gastrulating mouse embryos

2000 • 55 citations

Expression pattern of Dkk-1 during mouse limb development

1999 • 46 citations

3 The Organizer of the Gastrulating Mouse Embryo

1999 • 39 citations

Action of the Brachyury Gene in Mouse Embryogenesis

2007 • 31 citations

Whole Mount In Situ Hybridization to Study Gene Expression During Mouse Development

2003 • 15 citations