High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Interleukin-6 in human multiple myeloma

1995 • 550 citations

Multiple Myeloma

1997 • 389 citations

Phenotypic difference of normal plasma cells from mature myeloma cells

1993 • 323 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

Phenotypic difference of normal plasma cells from mature myeloma cells

1993 • 272 citations

Development, multiplexing, and application of ARMS tests for common mutations in the CFTR gene.

1992 • 246 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

RAS Mutations in Human Melanoma: A Marker of Malignant Progression

1994 • 221 citations

Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells

1994 • 220 citations

Methods for detection of point mutations: performance and quality assessment. IFCC Scientific Division, Committee on Molecular Biology Techniques.

1997 • 180 citations

Ras oncogene mutation in multiple myeloma.

1989 • 176 citations

Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors

1999 • 166 citations

Simplified hot start PCR

1996 • 161 citations

p53 and RAS gene mutations in multiple myeloma.

1992 • 157 citations

Methods for detection of point mutations: performance and quality assessment

1997 • 141 citations

The growth fraction of human myeloma cells

1981 • 139 citations

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing

1990 • 135 citations

Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias

1993 • 131 citations

Type and number of Ki-ras point mutations relate to stage of human colorectal cancer.

1994 • 111 citations

Stability of K-ras mutations throughout the natural history of human colorectal cancer

1992 • 100 citations

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1995 • 99 citations

Transformation and Plasmacytoid Differentiation of EBV-Infected Human B Lymphoblasts byrasOncogenes

1989 • 94 citations

Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).

1995 • 86 citations

Analysis of N-RAS exon-1 mutations in myelodysplastic syndromes by polymerase chain reaction and direct sequencing

1989 • 77 citations

Molecular typing for HLA class I using ARMS‐PCR: Further developments following the 12th International Histocompatibility Workshop

1999 • 76 citations

Restriction Endonuclease-Mediated Selective Polymerase Chain Reaction

1998 • 76 citations

THE BONE MARROW IN MULTIPLE MYELOMA: CORRELATION OF PLASMA CELL ULTRASTRUCTURE AND CLINICAL STATE

1975 • 75 citations

Disseminated aseptic abscesses associated with Crohn's disease: a new entity?

1998 • 67 citations

Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.

1997 • 59 citations

Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillaryelectrophoresis and allele specific polymerase chain reaction

1998 • 57 citations

Oncogenes in multiple myeloma: point mutation of N-ras.

1990 • 52 citations

Correlated flow cytometric analysis of H-ras p21 and nuclear DNA in multiple myeloma

1988 • 47 citations

The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system

1998 • 37 citations

N- and K-Ras Oncogenes in Plasma Cell Dyscrasias

1994 • 35 citations

Ras oncogene expression and DNA content in plasma cell dyscrasias: a flow cytofluorimetric study

1990 • 26 citations

Detection of the Most Common G6PD Gene Mutations in Chinese Using Amplification Refractory Mutation System

1999 • 24 citations

A high frequency of N-RAS oncogene mutations in multiple myeloma.

1992 • 22 citations

N-ras and p53 gene mutations are very rare events in multiple myeloma.

1995 • 21 citations

Enrichment polymerase chain reaction for the detection of Ki- ras mutations: relevance of Taq polymerase error rate, initial DNA copy number, and reaction conditions on the emergence of false-positive mutant bands

1999 • 20 citations

N-RAS gene activation in acute myeloid leukemia: association with expression of interleukin-6.

1993 • 15 citations

Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation

1997 • 14 citations

Rapid Quantitation of Gene Therapy Specific CFTR Expression Using the Amplification Refractory Mutation System

1999 • 13 citations

Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation.

1993 • 8 citations

Non-radioactive detection of K-rasmutations by nested allele specific PCR and oligonucleotide hybridization

1998 • 7 citations

A Multiplex ARMS Test for 10 Cystic Fibrosis (CF) Mutations: Evaluation in a Prenatal CF Screening Program

1998 • 7 citations

Point mutation in codon 61 of N-RAS genes in human myeloma cell lines

1989 • 4 citations

Allele-Specific Amplification for the Diagnosis of Autosomal Recessive Spinal Muscular Atrophy

1999 • 4 citations

The proliferation of multiple myeloma colonies (MY-CFUc) in vitro is independent of prognosis and is not associated with mutated N- or K-ras alleles in human bone marrow aspirates

1995 • 2 citations