Metalloproteinases in Multiple Myeloma: Production of Matrix Metalloproteinase-9 (MMP-9), Activation of proMMP-2, and Induction of MMP-1 by Myeloma Cells

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates

1980 • 1,991 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.

1990 • 408 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

1992 • 378 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Role of cytokines in bone resorption

1995 • 315 citations

Structure of the human type IV collagenase gene.

1990 • 310 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

Association Between Expression of Activated 72-Kilodalton Gelatinase and Tumor Spread in Non-Small-Cell Lung Carcinoma

1993 • 278 citations

Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease.

1989 • 240 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

1996 • 232 citations

Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells

1996 • 230 citations

Matrix metalloproteinase inhibition: A review of anti-tumour activity

1995 • 226 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.

1994 • 200 citations

Gelatinase A activity directly modulates melanoma cell adhesion and spreading.

1995 • 199 citations

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

1994 • 166 citations

Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines

1992 • 159 citations

Cytokine Network in Human Multiple Myeloma

1992 • 150 citations

Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin

1995 • 142 citations

Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

1994 • 131 citations

Quantifiable excess of bone resorption in monoclonal gammopathy is an early symptom of malignancy: a prospective study of 87 bone biopsies

1996 • 127 citations

Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.

1994 • 115 citations

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.

1995 • 109 citations

Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells

1995 • 102 citations

Peripheral blood monoclonal plasma cells as a predictor of survival in patients with multiple myeloma [see comments]

1996 • 99 citations

Peripheral blood monoclonal plasma cells as a predictor of survival in patients with multiple myeloma [see comments]

1996 • 96 citations

Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase

1995 • 95 citations

Progelatinase A activation during tumor cell invasion.

1994 • 79 citations

Quantitation of circulating peripheral blood plasma cells and their relationship to disease activity in patients with multiple myeloma

1993 • 73 citations

Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone

1996 • 52 citations

The gp 130 family cytokines IL‐6, LIF and OSM but not IL‐11 can reverse the anti‐proliferative effect of dexamethasone on human myeloma cells

1995 • 46 citations