Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

2000 • 511 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

Insulin-Like Growth Factors (IGFs), IGF Receptors, and IGF-Binding Proteins in Primary Cultures of Prostate Epithelial Cells*

1991 • 361 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study

2000 • 317 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Serum syndecan-1: a new independent prognostic marker in multiple myeloma

2000 • 241 citations

Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.

1993 • 227 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

Elevated Serum Concentrations of Hepatocyte Growth Factor in Patients With Multiple Myeloma

1998 • 214 citations

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines

1996 • 190 citations

ADAM 12, a Disintegrin Metalloprotease, Interacts with Insulin-like Growth Factor-binding Protein-3

2000 • 182 citations

Serum beta₂ microglobulin and survival duration in multiple myeloma: a simple reliable marker for staging.

1983 • 179 citations

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

2000 • 171 citations

A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin.

1996 • 163 citations

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

2000 • 154 citations

Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.

2000 • 139 citations

A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth.

1997 • 117 citations

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226.

1993 • 114 citations

Plasma Insulin-Like Growth Factor-I and Serum IGF-Binding Protein 3 Can Be Associated with the Progression of Breast Cancer, and Predict the Risk of Recurrence and the Probability of Survival in African-American and Hispanic Women

1999 • 112 citations

Expression of Members of the Novel Membrane Linked Metalloproteinase Family ADAM in Cells Derived from a Range of Haematological Malignancies

1997 • 102 citations

Insulin-like growth factors and breast cancer

1995 • 96 citations

Insulin-Like Growth Factor-1 Acts as a Chemoattractant Factor for 5T2 Multiple Myeloma Cells

1999 • 96 citations

High-risk colorectal adenomas and serum insulin-like growth factors

2001 • 89 citations

Predictive value of interleukin-6 and neopterin in patients with multiple myeloma.

1991 • 81 citations

Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines

1992 • 46 citations

Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells

2000 • 36 citations

Insulin-like growth factor (IGF)–binding protein-3 (IGFBP-3) proteolysis in patients with colorectal cancer: possible association with the metastatic potential of the tumor

1998 • 30 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: mutual relationship and possible correlations with patients' hormonal status

1995 • 28 citations

Plasma insulin-like growth factor binding protein-3 proteolysis is increased in primary breast cancer

2001 • 22 citations