Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

Phase I Clinical and Pharmacokinetic Study of Bcl-2 Antisense Oligonucleotide Therapy in Patients With Non-Hodgkin’s Lymphoma

2000 • 460 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 258 citations

IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway

1999 • 249 citations

BCL-X expression in multiple myeloma: possible indicator of chemoresistance.

1998 • 229 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 193 citations

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival.

1996 • 167 citations

Mcl‐1 and Bcl‐x_L are co‐regulated by IL‐6 in human myeloma cells

1999 • 157 citations

Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells

2000 • 143 citations

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6

2001 • 141 citations

Optimal detection of apoptosis by flow cytometry depends on cell morphology

1993 • 127 citations

Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells

2000 • 112 citations

A Constitutive Cytoprotective Pathway Protects Endothelial Cells from Lipopolysaccharide-induced Apoptosis

2001 • 109 citations

Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide

1996 • 99 citations

Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli

1999 • 91 citations

Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders

1999 • 66 citations

Reversal of EBV Immortalization Precedes Apoptosis in IL-6–Induced Human B Cell Terminal Differentiation

1997 • 61 citations

Differential expression of Bcl-2 in human plasma cell disorders according to proliferation status and malignancy

1999 • 56 citations

First- and second-generation antisense inhibitors targeted to human c-raf kinase: in vitro and in vivo studies.

1997 • 51 citations

The gp 130 family cytokines IL‐6, LIF and OSM but not IL‐11 can reverse the anti‐proliferative effect of dexamethasone on human myeloma cells

1995 • 46 citations

G₁Phase-Dependent Expression of Bcl-2 mRNA and Protein Correlates with Chemoresistance of Human Cancer Cells

2000 • 46 citations

bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: a comparative study.

1998 • 42 citations

Bcl-2 protein expression is not related to short survival in multiple myeloma.

1995 • 36 citations

Bcl-2 antisense therapy in multiple myeloma.

1999 • 21 citations