Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos

1991 • 2,082 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Wnt genes

1992 • 799 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb

1995 • 469 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1992 • 425 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

1994 • 407 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

F-spondin: A gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension

1992 • 382 citations

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

1994 • 379 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

1994 • 335 citations

Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis

1993 • 330 citations

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1995 • 321 citations

Identification of Distinct Classes and Functional Domains of Wnts through Expression of Wild-Type and Chimeric Proteins in Xenopus Embryos

1995 • 314 citations

Xwnt-11: a maternally expressed Xenopus wnt gene

1993 • 308 citations

Differential Transformation of Mammary Epithelial Cells by Wnt Genes

1994 • 305 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

The effects of N-cadherin misexpression on morphogenesis in xenopus embryos

1990 • 242 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Zebrafishwnt8andwnt8bshare a common activity but are involved in distinct developmental pathways

1995 • 231 citations

Overlapping Expression of Xwnt-3A and Xwnt-1 in Neural Tissue of Xenopus laevis Embryos

1993 • 202 citations

Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes

1993 • 198 citations

Chapter 5 Early Embryonic Development of Xenopus laevis

1991 • 198 citations

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

1994 • 197 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 185 citations

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant

1994 • 176 citations

Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps.

1994 • 156 citations

Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos

1990 • 152 citations

Induction of dorsal mesoderm by soluble, mature Vg1 protein

1995 • 150 citations

β-Catenin Has Wnt-like Activity and Mimics the Nieuwkoop Signaling Center inXenopusDorsal–Ventral Patterning

1995 • 142 citations

Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis

1995 • 139 citations

Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo

1995 • 129 citations

The Wnt family of developmental regulators

1992 • 121 citations

In pursuit of the functions of the Wnt family of developmental regulators: Insights from Xenopus laevis

1993 • 98 citations

Analysis of Xwnt-4 in embryos of Xenopus laevis: A Wnt family member expressed in the brain and floor plate

1992 • 88 citations

Overexpression of a homeodomain protein confers axis-forming activity to uncommitted xenopus embryonic cells

1991 • 88 citations

Induction of neuronal differentiation by planar signals in Xenopus embryos

1993 • 84 citations

Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.

1994 • 81 citations

The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death

1989 • 77 citations

Regulation of Wnt5a mRNA Expression in Human Mammary Epithelial Cells by Cell Shape, Confluence, and Hepatocyte Growth Factor

1995 • 65 citations

Dissecting Wnt signalling pathways and Wnf-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis

1993 • 53 citations

Mutants shed light on plant development

1992 • 14 citations

Analysis ofWnt/EngrailedSignaling inXenopusEmbryos Using Biolistics

1996 • 13 citations