Fatty Acid Oxidation and Signaling in Apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Lipid hydroperoxide generation, turnover, and effector action in biological systems

1998 • 1,188 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Dietary Conjugated Linoleic Acid Normalizes Impaired Glucose Tolerance in the Zucker Diabetic Fattyfa/faRat

1998 • 652 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Protein-bound acrolein: Potential markers for oxidative stress

1998 • 622 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Arachidonic acid as a bioactive molecule

2001 • 520 citations

The Molecular Effects of Acrolein

2000 • 514 citations

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1998 • 498 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2

1999 • 440 citations

Properties and Biological Activities of Thioredoxins

2001 • 437 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Intracellular unesterified arachidonic acid signals apoptosis

2000 • 423 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα

1999 • 402 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals

2000 • 345 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Inhibition of Human Lung Cancer Cell Growth by the Peroxisome Proliferator-Activated Receptor-γ Agonists through Induction of Apoptosis

2000 • 329 citations

Physiological properties and functions of intracellular fatty acid-binding proteins

1998 • 325 citations

Rescue of cells from apoptosis by inhibition of active GSH extrusion

1998 • 320 citations

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

2001 • 316 citations

Bcl-2 expression causes redistribution of glutathione to the nucleus

1998 • 297 citations

Current Status of Acrolein as a Lipid Peroxidation Product

1999 • 288 citations

Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

2001 • 284 citations

A critical review of the literature on acrolein toxicity

1985 • 277 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

1999 • 266 citations

Arachidonic Acid Stimulates Prostate Cancer Cell Growth: Critical Role of 5-Lipoxygenase

1997 • 262 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

1996 • 252 citations

4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

1999 • 249 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.

2000 • 247 citations

Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis

1994 • 245 citations

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

2001 • 241 citations

Saturated FFAs, Palmitic Acid and Stearic Acid, Induce Apoptosis in Human Granulosa Cells

2001 • 240 citations

Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.

1987 • 232 citations

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease

1998 • 231 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.

1996 • 228 citations

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

Reactive Oxygen Intermediate-Dependent NF-κB Activation by Interleukin-1β Requires 5-Lipoxygenase or NADPH Oxidase Activity

1999 • 224 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Acrolein-induced cell death: a caspase-influenced decision between apoptosis and oncosis/necrosis

2002 • 217 citations

4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death

2000 • 215 citations

A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis

2000 • 205 citations

Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

1994 • 205 citations

Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3‐L1 preadipocytes

2000 • 203 citations

Invited Commentary is Apoptosis Mediated by Reactive Oxygen Species?

1994 • 201 citations

Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions

1999 • 200 citations

Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines.

1995 • 200 citations

Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity

1999 • 194 citations

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

1995 • 189 citations

Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress

2001 • 185 citations

Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells

1999 • 183 citations

Acrolein-induced oxygen radical formation

1993 • 182 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Apoptosis Overview Emphasizing the Role of Oxidative Stress, DNA Damage and Signal- Transduction Pathways

1995 • 175 citations

Docosahexaenoic Acid, a Peroxisome Proliferator–Activated Receptor-α Ligand, Induces Apoptosis in Vascular Smooth Muscle Cells by Stimulation of p38 Mitogen-Activated Protein Kinase

2000 • 172 citations

Lipoxygenases and their involvement in programmed cell death

2001 • 169 citations

Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.

1986 • 167 citations

Conjugated Linoleic Acid Inhibits Proliferation and Induces Apoptosis of Normal Rat Mammary Epithelial Cells in Primary Culture

1999 • 163 citations

Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells

1999 • 160 citations

Essential fatty acids, lipid peroxidation and apoptosis

1999 • 160 citations

Signal Transduction by Interferon-α Through Arachidonic Acid Metabolism

1991 • 155 citations

Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon

1999 • 155 citations

Cellular Enrichment with Polyunsaturated Fatty Acids Induces an Oxidative Stress and Activates the Transcription Factors AP1 and NFκB

1999 • 155 citations

Biologically Active Oxidized Phospholipids

1999 • 154 citations

Cytochrome P450 Epoxygenase Metabolism of Arachidonic Acid Inhibits Apoptosis

2001 • 152 citations

Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886

2001 • 151 citations

Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.

1999 • 149 citations

Stimulation of prostaglandin synthesis by tumor-promoting phorbol-12, 13-diesters in canine kidney (MDCK) cells. Cycloheximide inhibits the stimulated prostaglandin synthesis, deacylation of lipids, and morphological changes

1978 • 142 citations

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)

1998 • 141 citations

Apoptosis

1997 • 141 citations

Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells

2000 • 139 citations

Fatty acids in cell signalling: Modulation by lipid binding proteins

1995 • 136 citations

Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase.

1988 • 135 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Peroxisome Proliferator–Activated Receptors: A Critical Link among Fatty Acids, Gene Expression and Carcinogenesis

1999 • 129 citations

Contribution of Cyclopentenone Prostaglandins to the Resolution of Inflammation Through the Potentiation of Apoptosis in Activated Macrophages

2000 • 128 citations

Effects of mGST A4 Transfection on 4-Hydroxynonenal-Mediated Apoptosis and Differentiation of K562 Human Erythroleukemia Cells

1999 • 124 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

Transfection of mGSTA4 in HL-60 Cells Protects against 4-Hydroxynonenal-Induced Apoptosis by Inhibiting JNK-Mediated Signaling

2001 • 122 citations

THE ISOPROSTANES: UNIQUE PROSTAGLANDIN-LIKE PRODUCTS OF FREE-RADICAL-INITIATED LIPID PEROXIDATION*

1999 • 121 citations

Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells

1994 • 119 citations

Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine

2000 • 119 citations

15-Deoxy-Δ12,14-prostaglandin J2, a Ligand for Peroxisome Proliferator-Activated Receptor-γ, Induces Apoptosis in JEG3 Choriocarcinoma Cells

1999 • 119 citations

Cytoplasmic fatty acid binding protein: Significance for intracellular transport of fatty acids and putative role on signal transduction pathways

1993 • 118 citations

Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids 1 1Abbreviations: AA, arachidonic acid; CsA, cyclosporin A; Cyt.c, cytochrome c; DCFH-DA, 2′,7′-dichlorofluorescein diacetate; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; HE, hydroethidine; JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol carbocyanine iodide; MPT, membrane permeability transition; PUFA, polyunsaturated fatty acid; ROS, reactive oxygen species; and z-VAD-fmk, z-Val-…

2001 • 118 citations

Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells

2000 • 117 citations

Leukotriene B4 and 12-Hydroxyeicosatetraenoic Acid Stimulate Epidermal Proliferation In Vivo in the Guinea Pig

1985 • 115 citations

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

1995 • 112 citations

Oxidative DNA damage — The effects of certain genotoxic and operationally non-genotoxic carcinogens

1994 • 110 citations

Intracellular redox changes during apoptosis.

1996 • 110 citations

4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells

1999 • 110 citations

12(S)-HETE Is a Mitogenic Factor for Microvascular Endothelial Cells: Its Potential Role in Angiogenesis

1995 • 109 citations

Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C.

1994 • 108 citations

Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPAR? agonists as inducers of apoptosis

2000 • 108 citations

Lipid hydroperoxide‐induced apoptosis: lack of inhibition by Bcl‐2 over‐expression

1995 • 108 citations

JunB Forms the Majority of the AP-1 Complex and Is a Target for Redox Regulation by Receptor Tyrosine Kinase and G Protein-coupled Receptor Agonists in Smooth Muscle Cells

1999 • 107 citations

Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland.

2000 • 106 citations

Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process

2001 • 103 citations

Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells

1996 • 102 citations

Nicotine protects against arachidonic‐acid‐induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons

2001 • 101 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

Proteolytic regulation of apoptosis

2000 • 99 citations

Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways.

1988 • 99 citations

5-lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death

1998 • 97 citations

Relationship between Arachidonate−Phospholipid Remodeling and Apoptosis

1996 • 97 citations

Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochromeC-dependent pathway in esophageal cancer cells

2001 • 95 citations

Human Calcium-independent Phospholipase A2 Mediates Lymphocyte Proliferation

2000 • 94 citations

Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: Role of 12-lipoxygenase in regulating tumor cell survival

1997 • 92 citations

Acrolein Causes Inhibitor κB-independent Decreases in Nuclear Factor κB Activation in Human Lung Adenocarcinoma (A549) Cells

1999 • 91 citations

Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.

2001 • 90 citations

Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells

1999 • 90 citations

Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism

1997 • 90 citations

The Binding Properties and Biological Activities of Bcl-2 and Bax in Cells Exposed to Apoptotic Stimuli

1998 • 89 citations

Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal

1997 • 89 citations

Arachidonic acid: Toxic and trophic effects on cultured hippocampal neurons

1994 • 86 citations

Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1.

1989 • 86 citations

Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase-dependent Pathway

2000 • 85 citations

Molecular and clinical aspects of apoptosis

1996 • 83 citations

4-Hydroxynonenal induces apoptosis, NF-κB-activation and formation of 8-isoprostane in vascular smooth nmuscle cells

2001 • 82 citations

Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.

1990 • 82 citations

Phospholipid Peroxidation Induces Cytosolic Phospholipase A2Activity: Membrane Effects versus Enzyme Phosphorylation

1997 • 82 citations

The Role of Fatty Acids and Eicosanoid Synthesis Inhibitors in Breast Carcinoma

1995 • 82 citations

Cell proliferation’ differentiation’ and apoptosis are modified by n−3 polyunsaturated fatty acids in normal colonic mucosa

1999 • 81 citations

Ebselen inhibition of apoptosis by reduction of peroxides

1996 • 75 citations

5-Lipoxygenase-activating protein (FLAP)

1995 • 73 citations

α,β-Unsaturated Aldehydes Increase GlutathioneS-Transferase mRNA and Protein: Correlation with Activation of the Antioxidant Response Element

1998 • 71 citations

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

1998 • 70 citations

Binding of Annexin V to Membrane Products of Lipid Peroxidation

2001 • 69 citations

Thiol Depletion Induces Apoptosis in Cultured Lung Fibroblasts

1999 • 68 citations

Effect of Rodent Hepatocarcinogenic Peroxisome Proliferators on Fatty Acyl-CoA Oxidase, DNA Synthesis, and Apoptosis in Cultured Human and Rat Hepatocytes

1998 • 67 citations

Glutathione Oxidation and Mitochondrial Depolarization as Mechanisms of Nordihydroguaiaretic Acid-Induced Apoptosis in Lipoxygenase-Deficient FL5.12 Cells

2000 • 66 citations

Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha- induced activation of the c-jun amino-terminal kinases in stromal cells

1996 • 65 citations

Prolonged, But Not Acute, Glutathione Depletion Promotes Fas–Mediated Mitochondrial Permeability Transition and Apoptosis in Mice

2001 • 65 citations

Protein Kinases C Translocation Responses to Low Concentrations of Arachidonic Acid

2001 • 65 citations

Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARα and TNFα

2000 • 64 citations

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.

1999 • 63 citations

Effect of eicosapentaenoic acid on the proliferation and incidence of apoptosis in the colorectal cell line HT29

1999 • 63 citations

Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites

2001 • 63 citations

Induction of Mitogen-activated Protein Kinase Phosphatase-1 by Arachidonic Acid in Vascular Smooth Muscle Cells

1998 • 62 citations

Eicosanoid Activation of Extracellular Signal-regulated Kinase1/2 in Human Epidermoid Carcinoma Cells

2000 • 62 citations

Inhibition of Cell Proliferation and AP-1 Activity by Acrolein in Human A549 Lung Adenocarcinoma Cells Due to Thiol Imbalance and Covalent Modifications

2002 • 62 citations

Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing

1998 • 58 citations

Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids

1997 • 57 citations

Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor.

1993 • 57 citations

Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2.

1988 • 57 citations

Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis

1995 • 56 citations

Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-Terminal protein kinase pathway

2001 • 53 citations

Human β-Cell Glucokinase

1995 • 52 citations

Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids

1997 • 52 citations

Involvement of caspases in 4-hydroxy-alkenal–induced apoptosis in human leukemic cells

2001 • 52 citations

An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells.

1996 • 52 citations

Saturated FFAs, Palmitic Acid and Stearic Acid, Induce Apoptosis in Human Granulosa Cells

2001 • 51 citations

Arachidonic acid induces DNA-fragmentation in human polymorphonuclear neutrophil granulocytes.

1997 • 50 citations

Induction of apoptosis and apoptotic mediators in balb/C splenic lymphocytes by dietary n−3 and n−6 fatty acids

1999 • 50 citations

Involvement of 5-lipoxygenase in programmed cell death of cancer cells

1997 • 49 citations

Possible induction of fatty acid cyclooxygenase in mouse osteoblastic cells (MC3T3-E1) by cAMP

1988 • 48 citations

A Relationship between 5-Lipoxygenase-activating Protein and bcl-xL Expression in Murine Pro-B Lymphocytic FL5.12 Cells

1998 • 45 citations

Anti-CD3 and Concanavalin A-induced Human T Cell Proliferation Is Associated with an Increased Rate of Arachidonate-Phospholipid Remodeling

2001 • 41 citations

Apoptosis in RAW 264.7 cells exposed to 4-hydroxy-2-nonenal: dependence on cytochrome C release but not p53 accumulation

2001 • 41 citations

Activation of the Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B Signaling Pathway in Arachidonic Acid-stimulated Human Myeloid and Endothelial Cells

2001 • 41 citations

Lipoxygenase inhibitors block CD95 ligand‐mediated apoptosis of human malignant glioma cells

1997 • 37 citations

Eicosanoid 12(S)-HETE Activates Phosphatidylinositol 3-Kinase

2000 • 33 citations

The Upstream Regulatory Region of the Carbamoyl-phosphate Synthetase I Gene Controls Its Tissue-specific, Developmental, and Hormonal Regulation in Vivo

1996 • 33 citations

Metabolism of the glutathione-acrolein adduct, S-(2-aldehydo-ethyl)glutathione, by rat liver alcohol and aldehyde dehydrogenase.

1989 • 32 citations

4-Hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic T- and B-cell lines

2000 • 32 citations

The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid

1996 • 31 citations

Activation of phosphoinositide‐specific phospholipase C of rat neutrophils by the chemotactic aldehydes 4‐hydroxy‐2,3‐trans‐nonenal and 4‐hydroxy‐2,3‐trans‐octenal

1994 • 29 citations

Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts

2001 • 28 citations

Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase

2000 • 24 citations

Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase

1993 • 24 citations

15-Hydroxyeicosatrienoic acid (15-HETrE) suppresses epidermal hyperproliferation via the modulation of nuclear transcription factor (AP-1) and apoptosis

2000 • 24 citations

Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils

2001 • 23 citations

Possible induction of fatty acid cyclooxygenase in mouse osteoblastic cells (MC3T3-E1) by cAMP

1988 • 23 citations

A 12( S )-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1

2000 • 22 citations

Leukotriene synthesis in U937 cells expressing recombinant 5-lipoxygenase.

1993 • 22 citations

A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death

1997 • 17 citations

Expression of 5-lipoxygenase in lymphoblastoid B and T cells

1994 • 17 citations

A genomic response of H-358 bronchiolar carcinoma cells to MK 886, an inhibitor of 5-lipoxygenase, assessed with a cDNA array.

2000 • 12 citations

Cyclooxygenase‐2 up‐regulation after FLAP transfection in human adenocarcinoma cell line HT29 cl.19A

1998 • 12 citations

Association between bcl-xL and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells

2001 • 6 citations

Proteolytic Loss of bcl-xL in FL5.12 Cells Undergoing Apoptosis Induced by MK886

2001 • 5 citations