Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C.

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Arachidonic Acid Cascade and Signal Transduction

1990 • 597 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells

1989 • 353 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes.

1993 • 146 citations

Role of fatty acids in signal transduction: Modulators and messengers

1993 • 144 citations

Regulation of gene transcription by polyunsaturated fatty acids

1993 • 139 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.

1990 • 130 citations

Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms

1992 • 127 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells

1991 • 122 citations

Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression.

1992 • 121 citations

Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.

1988 • 117 citations

Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester.

1989 • 108 citations

Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 cells is associated with platelet-derived growth-promoting activity.

1980 • 104 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

Is arachidonic acid a second messenger in signal transduction?

1991 • 98 citations

Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner

1989 • 97 citations

Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels.

1993 • 84 citations

Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes

1992 • 55 citations

Inhibition of phorbol ester-induced monocytic differentiation and c-fms gene expression by dexamethasone: potential involvement of arachidonic acid metabolites

1990 • 42 citations

Arachidonic acid regulates unsaturated fatty acid synthesis in lymphocytes by inhibiting stearoyl-CoA desaturase gene expression

1992 • 41 citations

Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids

1991 • 40 citations

Arachidonic Acid and Cyclic Adenosine Monophosphate Stimulation of c-fosExpression bya Pathway Independent of Phorbol Ester-Sensitive Protein Kinase C

1988 • 28 citations

Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C.

1991 • 23 citations

Activation of inositol phospholipid breakdown by prostaglandin F2α without any stimulation of proliferation in quiescent NIH-3T3 fibroblasts

1990 • 23 citations

Suppression of platelet-derived growth factor receptor tyrosine kinase activity by unsaturated fatty acids.

1993 • 18 citations

Modulation of c-jun and jun-B messenger RNA and inhibition of DNA synthesis by prostaglandin E2 in Syrian hamster embryo cells.

1992 • 18 citations