Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

1998 • 593 citations

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1998 • 498 citations

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

2000 • 481 citations

Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2

1999 • 440 citations

PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A

1997 • 379 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Inhibition of Human Lung Cancer Cell Growth by the Peroxisome Proliferator-Activated Receptor-γ Agonists through Induction of Apoptosis

2000 • 329 citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

1999 • 309 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 297 citations

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

1996 • 252 citations

5‐lipoxygenase‐activating protein is an arachidonate binding protein

1993 • 230 citations

Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

1994 • 205 citations

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)

1998 • 141 citations

Fatty acids in cell signalling: Modulation by lipid binding proteins

1995 • 136 citations

Peroxisome Proliferator–Activated Receptors: A Critical Link among Fatty Acids, Gene Expression and Carcinogenesis

1999 • 129 citations

15-Deoxy-Δ12,14-prostaglandin J2, a Ligand for Peroxisome Proliferator-Activated Receptor-γ, Induces Apoptosis in JEG3 Choriocarcinoma Cells

1999 • 119 citations

Cytoplasmic fatty acid binding protein: Significance for intracellular transport of fatty acids and putative role on signal transduction pathways

1993 • 118 citations

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

1992 • 112 citations

Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation

1983 • 109 citations

Lipid hydroperoxide‐induced apoptosis: lack of inhibition by Bcl‐2 over‐expression

1995 • 108 citations

Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPAR? agonists as inducers of apoptosis

2000 • 108 citations

The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP

1999 • 92 citations

Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells

1999 • 90 citations

Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism

1997 • 90 citations

Ebselen inhibition of apoptosis by reduction of peroxides

1996 • 75 citations

5-Lipoxygenase-activating protein (FLAP)

1995 • 73 citations

Effect of Rodent Hepatocarcinogenic Peroxisome Proliferators on Fatty Acyl-CoA Oxidase, DNA Synthesis, and Apoptosis in Cultured Human and Rat Hepatocytes

1998 • 67 citations

Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARα and TNFα

2000 • 64 citations

Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis

1995 • 56 citations

Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice

2000 • 54 citations

An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells.

1996 • 52 citations

Arachidonic acid induces DNA-fragmentation in human polymorphonuclear neutrophil granulocytes.

1997 • 50 citations

Non‐genotoxic Hepatocarcinogenesis: Suppression of Apoptosis by Peroxisome Proliferators

1996 • 47 citations

A Relationship between 5-Lipoxygenase-activating Protein and bcl-xL Expression in Murine Pro-B Lymphocytic FL5.12 Cells

1998 • 45 citations

Chemical Probes That Differentially Modulate Peroxisome Proliferator-activated Receptor α and BLTR, Nuclear and Cell Surface Receptors for Leukotriene B4

1999 • 45 citations

In vivo behavior of murine epidermal cell lines derived from initiated and noninitiated skin.

1988 • 37 citations

Peroxisome proliferators induce apoptosis and decrease DNA synthesis in hepatoma cell lines

2000 • 27 citations

Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase

1993 • 24 citations

A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death

1997 • 17 citations

Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells

1997 • 3 citations