Eicosanoid 12(S)-HETE Activates Phosphatidylinositol 3-Kinase

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

Protein Kinase C and the Cytoskeleton

1998 • 194 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer

1995 • 184 citations

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

1998 • 173 citations

Distinct Roles for the p110α and hVPS34 Phosphatidylinositol 3′-Kinases in Vesicular Trafficking, Regulation of the Actin Cytoskeleton, and Mitogenesis

1998 • 150 citations

Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase

2000 • 134 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

1994 • 105 citations

Chemoattractant Receptors Activate Distinct Pathways for Chemotaxis and Secretion

1999 • 99 citations

Regulation of melanoma‐cell motility by the lipoxygenase metabolite 12‐(S)‐hete

1993 • 75 citations

Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase.

1999 • 65 citations

The lipoxygenase metabolite 12(S)‐hete promotes α_llbβ₃integrin‐mediated tumor‐cell spreading on fibronectin

1992 • 64 citations

Eicosanoid Activation of Extracellular Signal-regulated Kinase1/2 in Human Epidermoid Carcinoma Cells

2000 • 62 citations

The Lipoxygenase Metabolite, 12(S)-HETE, Induces a Protein Kinase C-Dependent Cytoskeletal Rearrangement and Retraction of Microvascular Endothelial Cells

1993 • 57 citations

A Potential Role for Extracellular Signal-regulated Kinases in Prostaglandin F2α-induced Protein Synthesis in Smooth Muscle Cells

1999 • 51 citations

The priming effect of 12(S)-hydroxyeicosatetraenoic acid on lymphocyte phospholipase D involves specific binding sites

1999 • 8 citations