Eicosanoid Activation of Extracellular Signal-regulated Kinase1/2 in Human Epidermoid Carcinoma Cells

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Characterization of the human cysteinyl leukotriene CysLT1 receptor

1999 • 960 citations

Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes

1996 • 633 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

Identification, Molecular Cloning, Expression, and Characterization of a Cysteinyl Leukotriene Receptor

1999 • 349 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Platelets and cancer metastasis: A causal relationship?

1992 • 289 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor

1997 • 266 citations

Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase

1997 • 237 citations

12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

1994 • 202 citations

Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

1997 • 202 citations

Hyperosmolality Causes Growth Arrest of Murine Kidney Cells

1998 • 191 citations

Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer

1995 • 184 citations

Tyrphostins—Potential antiproliferative agents and novel molecular tools

1990 • 177 citations

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

1998 • 173 citations

Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1

1998 • 172 citations

Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway

1998 • 154 citations

Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 143 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

A Non-peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing

1995 • 123 citations

Inhibition of receptor/G protein coupling by suramin analogues.

1996 • 121 citations

Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.

1991 • 121 citations

Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.

1994 • 115 citations

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

1995 • 112 citations

Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.

1988 • 107 citations

Angiotensin II-induced Association of Phospholipase Cγ1 with the G-protein-coupled AT1 Receptor

1998 • 106 citations

A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

1994 • 105 citations

The lipoxygenase metabolite 12(S)‐hete induces a cytoskeleton‐dependent increase in surface expression of integrin α_iibβ₃ on melanoma cells

1991 • 97 citations

Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line

1996 • 88 citations

Identification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits

1998 • 79 citations

Regulation of melanoma‐cell motility by the lipoxygenase metabolite 12‐(S)‐hete

1993 • 75 citations

Protein-tyrosine-phosphatase-mediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cells

2000 • 72 citations

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

1998 • 70 citations

Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.

1994 • 68 citations

Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.

1994 • 66 citations

Transcriptional activation of endothelial cell integrin αv by protein kinase C activator 12(S)-HETE

1995 • 65 citations

The lipoxygenase metabolite 12(S)‐hete promotes α_llbβ₃integrin‐mediated tumor‐cell spreading on fibronectin

1992 • 64 citations

Identification of 12-Lipoxygenase Interaction with Cellular Proteins by Yeast Two-Hybrid Screening

2000 • 60 citations

Protein-tyrosine-phosphatase-mediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cells

2000 • 50 citations

Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D

1995 • 48 citations

Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation

1998 • 41 citations

12-Lipoxygenase in A431 Cells: Genetic Identity, Modulation of Expression, and Intracellular Localization

1996 • 32 citations

Melanoma cell spreading on fibronectin induced by 12(S)‐HETE involves both protein kinase C‐ and protein tyrosine kinase‐dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125^FAK)

1995 • 31 citations

Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho

1996 • 29 citations

From adjuvant to neo‐adjuvant chemotherapy in high‐risk breast cancer: The experience of the Milan Cancer Institute. Steiner award lecture 1992

1993 • 29 citations

12(S)-hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: A protein kinase-dependent process

1998 • 27 citations

A 12( S )-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1

2000 • 22 citations

The control of inositol lipid hydrolysis.

1996 • 21 citations

Role of Protein Kinase C and Phosphatases in 12(S)-Hete-Induced Tumor Cell Cytoskeletal Reorganization

1997 • 20 citations

Identification of subunits of the 650 kDa 12(S)-HETE binding complex in carcinoma cells

1998 • 16 citations

Coupling of adenosine receptors to adenylate cyclase in postischemic rat brain

1993 • 15 citations

Saturability of esterification pathways of major monohydroxyeicosatetraenoic acids in rat basophilic leukemia cells

1991 • 11 citations

Leukotriene D₄‐Induced Signal Transduction^a

1994 • 8 citations

The priming effect of 12(S)-hydroxyeicosatetraenoic acid on lymphocyte phospholipase D involves specific binding sites

1999 • 8 citations

Post soluble binding to the leukotriene D4 receptor from guinea pig lung membranes.

1990 • 2 citations