Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Germinal Centers

1994 • 1,680 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Death in Embryonic Systems

1966 • 943 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION

1991 • 650 citations

Regulators of cell death

1995 • 647 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Chapter 1 Anatomical Methods in Cell Death

1995 • 475 citations

Induction and activation of tissue transglutaminase during programmed cell death

1987 • 467 citations

Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis

1992 • 462 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry

1992 • 375 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast

1981 • 341 citations

RELATION OF THE PORTAL BLOOD TO LIVER MAINTENANCE

1920 • 340 citations

Viruses and apoptosis

1995 • 324 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

Apoptosis in metanephric development.

1992 • 310 citations

An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells

1975 • 300 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2

1992 • 284 citations

A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes

1965 • 255 citations

Programmed Cell Death in Terminally Differentiating Keratinocytes: Role of Endogenous Endonuclease

1991 • 248 citations

An electron-microscope study of cell deletion in the anuran tadpole tail during spontaneous metamorphosis with special reference to apoptosis of striated muscle fibres

1974 • 238 citations

A suggested explanation for the paradoxically slow growth rate of basal‐cell carcinomas that contain numerous mitotic figures

1972 • 227 citations

Apoptosis as the Mode of Uterine Epithelial Cell Death during Embryo Implantation in Mice and Rats1

1987 • 195 citations

Atrophy and apoptosis in the cyclical human endometrium

1976 • 192 citations

Adrenocortical cell deletion: The role of ACTH

1973 • 180 citations

Integrated control of cell proliferation and cell death by the c- myc oncogene

1994 • 151 citations

Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction

1987 • 147 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

Apoptosis and DNA fragmentation precede TNF‐induced cytolysis in U937 cells

1992 • 146 citations

Electron microscope study of palate fusion in mouse embryos

1968 • 145 citations

Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia

1986 • 144 citations

DNA degradation in terminally differentiating lens fiber cells from chick embryos.

1977 • 141 citations

Apoptosis

1979 • 137 citations

Properties of rapidly labelled deoxyribonucleic acid fragments isolated from the cytoplasm of primary cultures of embryonic mouse liver cells

1970 • 137 citations

bcl‐2 expression in normal breast tissue during the menstrual cycle

1994 • 129 citations

Cell death in the normal neonatal rat adrenal cortex

1973 • 121 citations

Internucleosomal dna fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud

1993 • 113 citations

Spontaneous Regression in Basal Cell Carcinomas

1979 • 112 citations

Apoptosis as the mechanism of the involution of hair follicles in catagen transformation

1981 • 100 citations

Relationships between DNA Fragmentation, Chromatin Condensation, and Changes in Flow Cytometry Profiles Detected during Apoptosis

1995 • 99 citations

A role for immunoglobulin D: interference with tolerance induction

1993 • 91 citations

Apoptosis of Human Adipocytes in Vitro

1994 • 90 citations

From AIDS to Parasite Infection: Pathogen‐Mediated Subversion of Programmed Cell Death as a Mechanism for Immune Dysregulation

1994 • 89 citations

Fate of senescent megakaryocytes in the bone marrow.

1983 • 88 citations

Patterns of cell death: the significance of apoptosis for dermatology

1993 • 87 citations

Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver

1988 • 86 citations

Ultrastructural observations on cell death by apoptosis in the ?resting? human breast

1981 • 83 citations

An electron‐microscope study of liver cell necrosis due to heliotrine

1969 • 80 citations

Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus

1985 • 77 citations

Granzyme B Plays a Critical Role in Cytotoxic Lymphocyte‐induced Apoptosis

1995 • 73 citations

Ultrastructure of the Rat Pancreas after Experimental Duct Ligation. II. Duct and Stromal Cell Proliferation, Differentiation, and Deletion

1992 • 68 citations

The digestion of cellular fragments within phagolysosomes in carcinoma cells

1972 • 67 citations

Apoptosis in the immune system

1994 • 66 citations

Macrophage recognition of senescent neutrophils

1992 • 61 citations

What is the value of bcl‐2 protein detection for histopathologists?

1995 • 59 citations

The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix

1973 • 59 citations

Shrinkage necrosis of adrenal cortical cells

1972 • 59 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

Biophysical and morphological correlates of kinetic change and death in a starved human melanoma cell line

1981 • 46 citations

Ethionine-Induced Atrophy of Rat Pancreas Involves Apoptosis of Acinar Cells

1993 • 44 citations

The role of the p53 and Rb-1 genes in cancer, development and apoptosis

1994 • 41 citations

Electron microscopic observation of destruction of biliary epithelium in primary biliary cirrhosis

1983 • 41 citations

On the expulsion of the erythroid nucleus and its phagocytosis

1972 • 39 citations

Neglected opportunities in apoptosis research

1995 • 37 citations

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.

1993 • 34 citations

Quantitative analysis of connective tissue resorption in the supra‐alveolar region of the mouse incisor ligament

1982 • 32 citations

An electron microscopic study of liver cell necrosis due to albitocin

1970 • 30 citations

The relationship of acute mesodermal cell death to the teratogenic effects of 7-OHM-12-MBA in the foetal rat

1972 • 23 citations

An ultrastructural study on the ?meconium corpuscles? in rat foetal intestinal epithelium with particular reference to apoptosis

1984 • 22 citations