Proteolytic regulation of apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Caspases: killer proteases

1997 • 2,440 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Proteases to die for

1998 • 1,241 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1995 • 774 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Apoptosis and disease

1993 • 684 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Caspase-9 and APAF-1 form an active holoenzyme

1999 • 566 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation

1999 • 502 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

1997 • 456 citations

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1999 • 449 citations

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1996 • 434 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats

1999 • 418 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation

1999 • 318 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

1999 • 291 citations

PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS

1998 • 282 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions

1997 • 262 citations

Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis

2000 • 248 citations

Bcl-2 and Bcl-XL Can Differentially Block Chemotherapy-Induced Cell Death

1997 • 243 citations

Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer

1999 • 240 citations

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

1997 • 237 citations

Characterization of seven murine caspase family members

1997 • 207 citations

Caspase-dependent Activation of Calpain during Drug-induced Apoptosis

1999 • 206 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases

1996 • 198 citations

Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions

1997 • 189 citations

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction

1999 • 144 citations

Fas Gene Mutation in the Progression of Adult T Cell Leukemia

1999 • 124 citations

Alterations of Fas (APO-1/CD95) gene in transitional cell carcinomas of urinary bladder.

1999 • 121 citations

Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases

1998 • 120 citations

Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex

1998 • 116 citations

Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region

1999 • 114 citations

Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster

1999 • 104 citations

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

1997 • 82 citations

Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2

1997 • 50 citations

Activation of apoptosis pathways by granzyme B.

1996 • 22 citations