Lipid hydroperoxide generation, turnover, and effector action in biological systems

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1991 • 17,840 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Beyond Cholesterol

1989 • 6,533 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

HOW DOES PHOTODYNAMIC THERAPY WORK?

1992 • 2,366 citations

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Free Radicals in Biology

1976 • 1,879 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Photosensitized Oxidation and Singlet Oxygen: Consequences in Biological Systems

1976 • 827 citations

Oxygen radical chemistry of polyunsaturated fatty acids

1989 • 716 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Mechanisms of lipid peroxidation

1985 • 542 citations

PHOTODYNAMIC LIPID PEROXIDATION IN BIOLOGICAL SYSTEMS

1990 • 531 citations

Lipid Peroxidation: Mechanisms, Analysis, Enzymology and Biological Relevance

1985 • 520 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

A study of the reactivity of HO2/O2- with unsaturated fatty acids.

1983 • 519 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

The kinetics of the autoxidation of polyunsaturated fatty acids

1987 • 507 citations

New insights on mammalian phospholipase A ₂ (s); comparison of arachidonoyl‐selective and ‐nonselective enzymes

1993 • 443 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

Differential regulation of antioxidant enzymes in response to oxidants.

1991 • 411 citations

Lifetime of oxygen (O2(1.DELTA.g)) in liquid water as determined by time-resolved infrared luminescence measurements

1982 • 407 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

The role of selenium peroxidases in the protection against oxidative damage of membranes

1987 • 386 citations

Mutagenicity of quinones: pathways of metabolic activation and detoxification.

1984 • 384 citations

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

1997 • 373 citations

Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability Is a Function of Cell Lipid bis-Allylic Hydrogen Content

1994 • 350 citations

High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress

1996 • 312 citations

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

1995 • 311 citations

Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation

1989 • 294 citations

Self-reaction of sec-butylperoxy radicals. Confirmation of the Russell mechanism

1968 • 288 citations

Mechanisms of radical formation from reactions of ozone with target molecules in the lung

1994 • 287 citations

New trends in photobiology the interaction of UVA radiation with cultured cells

1990 • 276 citations

PHOTOMODIFICATION OF BIOLOGICAL MEMBRANES WITH EMPHASIS ON SINGLET OXYGEN MECHANISMS

1987 • 275 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Oxidative stress-induced apoptosis prevented by trolox

1994 • 266 citations

The Science of Photobiology

1989 • 257 citations

Nitric Oxide Inhibition of Lipid Peroxidation: Kinetics of Reaction with Lipid Peroxyl Radicals and Comparison with α-Tocopherol

1997 • 252 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1997 • 240 citations

Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay

1989 • 234 citations

[26] Low-level chemiluminescence as an indicator of singlet molecular oxygen in biological systems

1984 • 231 citations

Sterol metabolism. XXV. Cholesterol oxidation by singlet molecular oxygen

1973 • 225 citations

Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence.

1994 • 200 citations

Biochemical effects of environmental pollutants

1978 • 196 citations

Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells.

1993 • 179 citations

SINGLET OXYGEN INVOLVEMENT IN THE INACTIVATION OF CULTURED HUMAN FIBROBLASTS BY UVA (334 nm, 365 nm) AND NEAR‐VISIBLE (405 nm) RADIATIONS

1989 • 177 citations

Non‐reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids

1983 • 171 citations

Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins

1990 • 171 citations

Cytotoxicity from Coupled Redox Cycling of Autoxidizing Xenobiotics and Metals: A Selective Critical Review and Commentary on Work‐in‐Progress

1984 • 170 citations

Apoptosis or Necrosis Following Photofrin® Photosensitization: Influence of the Incubation Protocol

1996 • 169 citations

Generation of H2O2 in biomembranes

1982 • 158 citations

Analysis of Free Radicals in Biological Systems

1995 • 153 citations

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.

1994 • 149 citations

Trolox Inhibits Peroxynitrite-Mediated Oxidative Stress and Apoptosis in Rat Thymocytes

1996 • 140 citations

Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical

1996 • 140 citations

BIOLOGICAL ACTIVITIES OF PHTHALOCYANINES—IV. TYPE II SENSITIZED PHOTOOXIDATION OF L‐TRYPTOPHAN AND CHOLESTEROL BY SULFONATED METALLO PHTHALOCYANINES

1986 • 139 citations

Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper

1996 • 135 citations

Zur photosensibilisierten Autoxydation der Steroide. Darstellung von Steroid‐Hydroperoxyden Mittels Phototoxischer Photosensibilisatoren

1957 • 130 citations

Cholesterol autoxidation

1982 • 127 citations

Cholesterol autoxidation in phospholipid membrane bilayers

1987 • 127 citations

Polyunsaturated fatty acid alkoxyl radicals exist as carbon-centered epoxyallylic radicals: A key step in hydroperoxide-amplified lipid peroxidation

1993 • 125 citations

Sterol metabolism. XXIII. Cholesterol oxidation by radiation-induced processes

1973 • 123 citations

SPECTRAL DEPENDENCE OF UV‐INDUCED IMMEDIATE AND DELAYED APOPTOSIS: THE ROLE OF MEMBRANE AND DNA DAMAGE

1995 • 122 citations

The Sphingomyelin-Ceramide Signaling Pathway Is Involved in Oxidized Low Density Lipoprotein-induced Cell Proliferation

1996 • 119 citations

Reactivity of singlet molecular oxygen with cholesterol in a phospholipid membrane matrix. A model for oxidative damage of membranes

1977 • 112 citations

[38] Assay of lipid hydroperoxides using high-performance liquid chromatography with isoluminal chemiluminescence detection

1990 • 100 citations

The mechanisms of the rearrangements of allylic hydroperoxides: 5α-hydroperoxy-3β-hydroxycholest-6-ene and 7α-hydroperoxy-3β-hydroxycholest-5-ene

1989 • 99 citations

Involvement of Preexisting Lipid Hydroperoxides in Cu2+-Stimulated Oxidation of Low-Density Lipoprotein

1994 • 99 citations

PHOTOPEROXIDATION OF CHOLESTEROL IN HOMOGENEOUS SOLUTION, ISOLATED MEMBRANES, AND CELLS: COMPARISON OF THE 5α‐ AND 6β‐HYDROPEROXIDES AS INDICATORS OF SINGLET OXYGEN INTERMEDIACY

1992 • 91 citations

New trends in photobiology

1992 • 90 citations

The molecular and cellular pathology of solar ultraviolet radiation.

1994 • 88 citations

Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells

1994 • 87 citations

Cell fatty acid composition affects free radical formation during lipid peroxidation

1994 • 86 citations

Photoinduced free radicals from chlorpromazine and related phenothiazines: relationship to phenothiazine-induced photosensitization.

1985 • 83 citations

What Does Ozone React with at the Air Lung Interface? Model Studies Using Human Red Blood Cell Membranes

1995 • 83 citations

Phospholipid Peroxidation Induces Cytosolic Phospholipase A2Activity: Membrane Effects versus Enzyme Phosphorylation

1997 • 82 citations

Expression of Human Phospholipid Hydroperoxide Glutathione Peroxidase Gene for Protection of Host Cells from Lipid Hydroperoxide-Mediated Injury

1996 • 79 citations

Greater selective uptake by Hep G2 cells of high-density lipoprotein cholesteryl ester hydroperoxides than of unoxidized cholesteryl esters

1993 • 78 citations

Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Suppressed Cell Death Due to Oxidative Damage in Rat Basophile Leukemia Cells (RBL-2H3)

1996 • 77 citations

Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene

1996 • 75 citations

Ebselen inhibition of apoptosis by reduction of peroxides

1996 • 75 citations

Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action

1991 • 73 citations

Superoxide and hydrogen peroxide-dependent lipid peroxidation in intact and Triton-dispersed erythrocyte membranes

1984 • 72 citations

Cholesterylester hydroperoxide reducing activity associated with isolated high- and low-density lipoproteins

1995 • 72 citations

PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria

1995 • 70 citations

Effects of fatty acids on human platelet glutathione peroxidase: possible role of oxidative stress

1997 • 67 citations

High-performance liquid chromatography with mercury cathode electrochemical detection: application to lipid hydroperoxide analysis

1995 • 62 citations

Photooxidation of cell membranes in the presence of hematoporphyrin derivative: reactivity of phospholipid and cholesterol hydroperoxides with glutathione peroxidase

1988 • 61 citations

Lipid Peroxidation in Photodynamically Stressed Mammalian Cells: Use of Cholesterol Hydroperoxides as Mechanistic Reporters

1997 • 57 citations

Bone Marrow Processing and Purging: a Practical Guide

1991 • 55 citations

Radiation-Induced Apoptosis in HL60 Cells: Oxygen Effect, Relationship between Apoptosis and Loss of Clonogenicity, and Dependence of Time to Apoptosis on Radiation Dose

1996 • 54 citations

Reaction of ozone with phospholipid vesicles and human erythrocyte ghosts

1979 • 54 citations

Analysis of Cholesterol and Phospholipid Hydroperoxides by High-Performance Liquid Chromatography with Mercury Drop Electrochemical Detection

1993 • 53 citations

Singlet oxygen in copper‐catalyzed lipid peroxidation in erythrocyte membranes

1984 • 52 citations

Photodynamic Action of Merocyanine 540 on Leukemia Cells: Iron-Stimulated Lipid Peroxidation and Cell Killing

1993 • 48 citations

Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells.

1992 • 46 citations

Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells

1993 • 45 citations

Enzymatic Reducibility in Relation to Cytotoxicity for Various Cholesterol Hydroperoxides

1996 • 44 citations

Ozone-induced tolerance to hyperoxia in rats.

1984 • 43 citations

Characterization of lipid hydroperoxides generated by photodynamic treatment of leukemia cells

1994 • 42 citations

Studies on the mechanism of ozone inactivation of erythrocyte membrane (Na+ + K+)-activated ATPase

1977 • 40 citations

Induction of Antioxidant Enzymes and DT-Diaphorase in Human Blood Mononuclear Cells by Light Stress

1993 • 36 citations

Reaction of Phosphatidylcholine Hydroperoxide in Human Plasma: The Role of Peroxidase and Lecithin:Cholesterol Acyltransferase

1996 • 34 citations

PHOTODYNAMICALLY GENERATED 3‐β‐HYDROXY‐5α‐CHOLEST‐6‐ENE‐5‐HYDROPEROXIDE: TOXIC REACTIVITY IN MEMBRANES and SUSCEPTIBILITY TO ENZYMATIC DETOXIFICATION

1995 • 31 citations

Apoptosis: O death, where is thy sting?

1995 • 24 citations

Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells

1996 • 20 citations

SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS. XVIII. INDOMETHACIN

1993 • 14 citations

Lipid hydroperoxide analysis by reverse-phase high-performance liquid chromatography with mercury cathode electrochemical detection

1995 • 2 citations