5-Lipoxygenase-activating protein (FLAP)

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

5-lipoxygenase inhibitory activity of zileuton.

1991 • 409 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

1989 • 337 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

1986 • 311 citations

Structure and function of epidermal growth factor‐like regions in proteins

1988 • 305 citations

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

1994 • 296 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

5‐lipoxygenase‐activating protein is an arachidonate binding protein

1993 • 230 citations

5‐Lipoxygenase‐activating protein stimulates the utilization of arachidonic acid by 5‐lipoxygenase

1993 • 215 citations

Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.

1990 • 191 citations

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

1992 • 112 citations

Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)

1991 • 98 citations

Membrane association of active 5-lipoxygenase in resting cells. Evidence for novel regulation of the enzyme in the rat alveolar macrophage.

1992 • 81 citations

Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity

1988 • 79 citations

Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 {(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid} and structurally related compounds

1993 • 78 citations

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

1993 • 73 citations

Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis

1991 • 72 citations

5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.

1991 • 71 citations

Leukotrienes as a Target in Asthma Therapy

1994 • 67 citations

Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.

1992 • 65 citations

Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells.

1988 • 63 citations

5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease.

1992 • 62 citations

Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.

1991 • 49 citations

Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors.

1992 • 49 citations

Pre‐clinical pharmacology of ICI D2138, a potent orally‐active non‐redox inhibitor of 5‐lipoxygenase

1992 • 45 citations

Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells

1992 • 43 citations

Leukotrienes and Lipoxygenases

1990 • 43 citations

Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition.

1992 • 39 citations

5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors.

1992 • 37 citations

Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein

1994 • 28 citations

Kinetics of leukotriene A4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes

1987 • 27 citations

5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease

1992 • 26 citations

Expression of 5-lipoxygenase and biosynthesis of leukotriene B4 in human monomorphonuclear leukocytes.

1993 • 23 citations

Leukotriene synthesis in U937 cells expressing recombinant 5-lipoxygenase.

1993 • 22 citations

The binding of leukotriene biosynthesis inhibitors to site-directed mutants of human 5-lipoxygenase-activating protein

1994 • 19 citations

Leukotrienes and lipoxygenases

1990 • 15 citations

Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591.

1993 • 14 citations

Cross-species comparison of 5-lipoxygenase-activating protein.

1992 • 13 citations

The Effect of 5-Lipoxygenase-Activating Protein (Flap) on Substrate Utilization by 5-Lipoxygenase

1997 • 3 citations