The Structure, Regulation and Function of the Janus Kinases (JAKs) and the Signal Transducers and Activators of Transcription (STATs)

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Cytokine signal transduction

1994 • 1,358 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

1995 • 460 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

1996 • 375 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.

1994 • 308 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

HEMATOPOIETIC RECEPTOR COMPLEXES

1996 • 298 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases

1995 • 249 citations

Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways

1997 • 248 citations

Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins

1996 • 247 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction

1996 • 243 citations

α and α Interferons and Their Receptor and Their Friends and Relations

1995 • 243 citations

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 239 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver

1996 • 225 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.

1994 • 224 citations

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

1996 • 223 citations

Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor

1996 • 221 citations

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

1995 • 220 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling

1995 • 217 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

Interactions between STAT and Non-STAT Proteins in the Interferon-Stimulated Gene Factor 3 Transcription Complex

1996 • 203 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon-α

1996 • 196 citations

JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone

1995 • 194 citations

The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors

1997 • 193 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

1994 • 183 citations

Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation

1996 • 182 citations

A Single Tyrosine of the Interleukin-9 (IL-9) Receptor Is Required for STAT Activation, Antiapoptotic Activity, and Growth Regulation by IL-9

1996 • 182 citations

Activation of Different Stat5 Isoforms Contributes to Cell-Type-Restricted Signaling in Response to Interferons

1996 • 176 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase

1996 • 176 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Proline-rich Sequence-mediated Jak2 Association to the Prolactin Receptor Is Required but Not Sufficient for Signal Transduction

1995 • 172 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1995 • 168 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 165 citations

Nuclear Factor I and Mammary Gland Factor (STAT5) Play a Critical Role in Regulating Rat Whey Acidic Protein Gene Expression in Transgenic Mice

1995 • 163 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

1996 • 156 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

1994 • 150 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction

1995 • 148 citations

The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain

1995 • 148 citations

JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells.

1994 • 145 citations

Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors

1994 • 144 citations

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.

1994 • 144 citations

PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.

1996 • 144 citations

The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction.

1994 • 141 citations

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.

1994 • 136 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 135 citations

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells

1996 • 133 citations

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.

1995 • 126 citations

JAK protein tyrosine kinases: their role in cytokine signalling

1994 • 125 citations

Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling

1996 • 124 citations

Stat5 is a physiological substrate of the insulin receptor

1997 • 122 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

Mutational analysis of the intracellular domain of the human growth hormone receptor

1993 • 120 citations

Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts

1995 • 119 citations

Regulation of mammary gland factor/Stat5a during mammary gland development.

1995 • 119 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4

1996 • 112 citations

Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain

1995 • 111 citations

Modulation of Interferon (IFN)-inducible Gene Expression by Retinoic Acid

1996 • 110 citations

Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction.

1995 • 109 citations

Lactogenic Hormone Activation of Stat5 and Transcription of the β-Casein Gene in Mammary Epithelial Cells Is Independent of p42 ERK2 Mitogen-activated Protein Kinase Activity

1996 • 108 citations

Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding

1996 • 105 citations

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5

1995 • 105 citations

Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

1995 • 101 citations

The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression

1996 • 100 citations

Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling

1995 • 98 citations

Interleukin‐6‐induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin‐6 target gene induction

1995 • 97 citations

Molecular Characterization of an Alpha Interferon Receptor 1 Subunit (IFNaR1) Domain Required for TYK2 Binding and Signal Transduction

1996 • 91 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.

1994 • 89 citations

Constitutive Activation of JAK1 in Src-transformed Cells

1997 • 88 citations

Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation

1995 • 86 citations

An Epidermal Growth Factor Receptor/Jak2 Tyrosine Kinase Domain Chimera Induces Tyrosine Phosphorylation of Stat5 and Transduces a Growth Signal in Hematopoietic Cells

1996 • 85 citations

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.

1996 • 84 citations

Cytokines and Growth factors signal through tyrosine phosphorylation of a family of related transcription factors

1994 • 84 citations

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines

1996 • 83 citations

Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.

1994 • 82 citations

Characterization of Specific DNA-binding Factors Activated by Double-stranded RNA as Positive Regulators of Interferon α/β-stimulated Genes

1995 • 82 citations

A Novel STAT-Like Factor Mediates Lipopolysaccharide, Interleukin 1 (IL-1), and IL-6 Signaling and Recognizes a Gamma Interferon Activation Site-Like Element in the IL1B Gene

1996 • 82 citations

Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus

1995 • 81 citations

IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).

1996 • 79 citations

Signaling by the Cytokine Receptor Superfamily in Normal and Transformed Hematopoietic Cells

1996 • 79 citations

Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.

1996 • 78 citations

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5

1995 • 77 citations

Regulation of JAK3 expression and activation in human B cells and B cell malignancies.

1995 • 76 citations

Homodimerization of Interleukin-4 Receptor α Chain Can Induce Intracellular Signaling

1996 • 75 citations

Expression of Janus Kinase 3 in Human Endothelial and Other Non-lymphoid and Non-myeloid Cells

1996 • 74 citations

A JAK-STAT pathway regulates wing vein formation in Drosophila.

1996 • 74 citations

Insulin Stimulates the Serine Phosphorylation of the Signal Transducer and Activator of Transcription (STAT3) Isoform

1996 • 73 citations

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines

1996 • 72 citations

A Membrane-Proximal Region of the Interleukin-2 Receptor γ_c Chain Sufficient for Jak Kinase Activation and Induction of Proliferation in T Cells

1996 • 69 citations

Association of JAK2 and STAT5 with Erythropoietin Receptors

1996 • 67 citations

Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the β Chain and Non-tyrosine Residues of the γc Chain

1995 • 67 citations

The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2 Activation and Functions Mitogenically within an Interleukin 2 β-Receptor Chimera

1996 • 67 citations

A Kinase-deficient Splice Variant of the Human JAK3 Is Expressed in Hematopoietic and Epithelial Cancer Cells

1995 • 65 citations

The JAK-STAT pathway in Drosophila

1997 • 65 citations

The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells

1994 • 61 citations

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2

1995 • 58 citations

Signal Transduction: Just another signalling pathway

1994 • 58 citations

Genomic Sequence, Organization, and Chromosomal Localization of HumanJAK3

1996 • 55 citations

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 • 53 citations

Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos

1997 • 52 citations

STAT protein complexes activated by interferon-γ and gp 130 signaling molecules differ in their sequence preferences and trascriptional induction properties

1995 • 52 citations

Receptors for interleukin-3 (IL-3) and growth hormone mediate an IL-6- type transcriptional induction in the presence of JAK2 or STAT3

1995 • 49 citations

Mapping of the Cytoplasmic Domain of the Human Growth Hormone Receptor Required for the Activation of Jak2 and Stat Proteins

1995 • 49 citations

Regulation of mammary gland factor/Stat5a during mammary gland development

1995 • 46 citations

Characterization of Active and Inactive Forms of the JAK2 Protein-tyrosine Kinase Produced via the Baculovirus Expression Vector System

1995 • 43 citations

Monocyte function in a severe combined immunodeficient patient with a donor splice site mutation in the Jak3 gene

1996 • 42 citations

Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins

1995 • 39 citations

A Negative Regulatory Region in the Intracellular Domain of the Human Interferon-α Receptor

1996 • 38 citations

Insulin Modulates STAT3 Protein Activation and Gene Transcription in Hepatic Cells

1996 • 37 citations

Signal Transduction by a CD16/CD7/Jak2 Fusion Protein

1995 • 35 citations

Maternal T-cell Engraftment Associated With Severe Hemophagocytosis of the Bone Marrow in Untreated X-linked Severe Combined Immunodeficiency

2008 • 34 citations

Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes

1994 • 34 citations

Signal transduction through homo- or heterodimers of gp130.

1994 • 27 citations

Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.

1996 • 27 citations

Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation.

1996 • 24 citations

Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes.

1996 • 19 citations

Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcription.

1996 • 13 citations

Genomic Structure and Promoter Region of the Murine Janus-Family Tyrosine Kinase, Jak3

1997 • 12 citations