The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Cytokine signal transduction

1994 • 1,358 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.

1990 • 192 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

1994 • 183 citations

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

1993 • 177 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction

1995 • 148 citations

The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain

1995 • 148 citations

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

1995 • 90 citations

Cytokines and Growth factors signal through tyrosine phosphorylation of a family of related transcription factors

1994 • 84 citations

Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements

1994 • 80 citations

Point Mutations in theablSH2 Domain Coordinately Impair Phosphotyrosine Binding In Vitro and Transforming Activity In Vivo

1992 • 70 citations

Activation of the protein tyrosine kinase tyk2 by interferon α/β

1994 • 59 citations

IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements.

1994 • 48 citations

γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors

1995 • 38 citations

Direct Binding to and Tyrosine Phosphorylation of the a Subunit of the Type I Interferon Receptor by p135^tyk2 Tyrosine Kinase

1994 • 36 citations

Resistance of melanoma cell lines to interferons correlates with reduction of IFN-induced tyrosine phosphorylation. Induction of the anti-viral state by IFN is prevented by tyrosine kinase inhibitors.

1995 • 26 citations

Construction of an SH2 Domain-binding Site with Mixed Specificity

1995 • 21 citations