Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.

1992 • 342 citations

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

The hematopoietin receptor superfamily

1993 • 296 citations

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 • 275 citations

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.

1994 • 242 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

1990 • 138 citations

Rational design of a receptor super-antagonist of human interleukin-6.

1994 • 134 citations

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

1994 • 132 citations

Development of a human interleukin-6 receptor antagonist.

1994 • 110 citations

The Crystal Structure of Affinity-matured Human Growth Hormone at 2 Å Resolution

1994 • 110 citations

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

1994 • 102 citations

Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.

1993 • 72 citations

Recombinant soluble human interleukin‐6 receptor

1993 • 67 citations

Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors

1994 • 57 citations

Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA

1991 • 53 citations

Direct association of interleukin-6 with a 130-kDa component of the interleukin-6 receptor system.

1993 • 21 citations