Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases

1995 • 249 citations

Ligand-Induced Autoregulation of IFN-γ Receptor β Chain Expression in T Helper Cell Subsets

1995 • 219 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75.

1995 • 163 citations

Interaction between the Components of the Interferon γ Receptor Complex

1995 • 160 citations

The Jak Kinases Differentially Associate with the α and β (Accessory Factor) Chains of the Interferon γ Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors

1995 • 143 citations

Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding

1996 • 105 citations

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

1992 • 102 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

1991 • 97 citations

Tissue-specific targeting of gytokine unresponsiveness in transgenic mice

1995 • 94 citations

Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.

1995 • 93 citations

Generation and characterization of monoclonal antibodies specific for the human IFN-gamma receptor.

1988 • 78 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Inactivation of Erythropoietin Receptor Function by Point Mutations in a Region Having Homology with other Cytokine Receptors

1993 • 45 citations

Immunoadhesins: An Alternative to Human Monoclonal Antibodies

1995 • 14 citations