Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Mechanism of met oncogene activation

1986 • 551 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Defectiveness of Interferon Production and of Rubella Virus Interference in a Line of African Green Monkey Kidney Cells (Vero)

1968 • 483 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2

1989 • 280 citations

Role of STAT2 in the Alpha Interferon Signaling Pathway

1995 • 280 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Activation of the human beta-interferon gene requires an interferon-inducible factor.

1986 • 237 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.

1991 • 147 citations

Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.

1991 • 132 citations

Two Domains of ISGF3γ That Mediate Protein-DNA and Protein-Protein Interactions during Transcription Factor Assembly Contribute to DNA-Binding Specificity

1993 • 124 citations

Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins

1992 • 122 citations

Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway

1989 • 106 citations

Activation of the Human β-Interferon Gene Requires an Interferon-Inducible Factor

1986 • 78 citations

Structure, Chromosome Localization, and Regulation of Expression of the Interferon-Regulated Mouse Ifi54/Ifi56 Gene Family

1994 • 60 citations

The interferon‐stimulable response elements of two human genes detect overlapping sets of transcription factors

1993 • 42 citations

The interferon‐stimulated gene 54 K promoter contains two adjacent functional interferon‐stimulated response elements of different strength, which act synergistically for maximal interferon‐α inducibility

1994 • 39 citations

Transcriptional induction of IFN-γ-responsive genes is modulated by DNA surrounding the interferon stimulation response element

1992 • 19 citations