Constitutive Activation of JAK1 in Src-transformed Cells

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

de la Chapelle, A.

1997 • 3,184 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

1995 • 460 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

1993 • 404 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

1996 • 375 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.

1995 • 307 citations

Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

1993 • 285 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Genetics of src: Structure and Functional Organization of a Protein Tyrosine Kinase

1989 • 197 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

1994 • 162 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).

1989 • 105 citations

Evidence for involvement of the growth hormone receptor-associated tyrosine kinase in actions of growth hormone.

1993 • 101 citations

Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

1995 • 101 citations

The Janus Kinase Family and Signaling Through Members of the Cytokine Receptor Superfamily

1994 • 75 citations

In vivo phosphorylation states and kinase activities of transforming p60c-src mutants.

1989 • 21 citations