An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

GATA transcription factors: key regulators of hematopoiesis.

1995 • 430 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Efficient infection of monkey cells with DNA of simian virus 40.

1981 • 419 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

1995 • 280 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Cloning of Human Stat5B

1996 • 210 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.

1995 • 93 citations

Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.

1995 • 74 citations

Interleukin‐2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes

1994 • 69 citations

cis-Acting Sequences Required for Inducible Interleukin-2 Enhancer Function Bind a Novel Ets-Related Protein, Elf-1

1992 • 66 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.

1995 • 51 citations

Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.

1989 • 49 citations

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.

1990 • 41 citations

Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.

1990 • 37 citations

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.

1996 • 33 citations

Sp1 represses IL-2 receptor alpha chain gene expression.

1990 • 22 citations

Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.

1989 • 20 citations

HMG-I Binds to GATA Motifs: Implications for an HPFH Syndrome

1995 • 15 citations

Sequencing Homopolymer Tracts and Repetitive Elements

1996 • 15 citations

Delineation of an Enhancerlike Positive Regulatory Element in the Interleukin-2 Receptor α-Chain Gene

1990 • 11 citations

Methylation Interference Assay for Analysis of DNA‐Protein Interactions

1988 • 8 citations