DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Cytokine receptor signalling

1995 • 1,242 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

lac repressor-operator interaction

1970 • 791 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Influence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins

1996 • 538 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

DNA binding properties of the purified Antennapedia homeodomain.

1990 • 193 citations

Direct protein microsequencing from Immobilon-P Transfer Membrane.

1988 • 178 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Probing the solution structure of the DNA‐binding protein Max by a combination of proteolysis and mass spectrometry

1995 • 161 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

1995 • 129 citations

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

1985 • 98 citations

IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties.

1995 • 59 citations

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2

1995 • 58 citations

Qualitative and Quantitative Studies of Protein-DNA Interactions by Gel Mobility-Shift Assay

1991 • 11 citations