The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Cytokine signal transduction

1994 • 1,358 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

PCR Technology: Principles and Applications for DNA Amplification

1989 • 689 citations

After Insulin Binds

1987 • 687 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

A simple method for site-directed mutagenesis using the polymerase chain reaction

1989 • 607 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

PCR Technology: Principles and Applications for DNA Amplification

1990 • 512 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

1991 • 499 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface

1986 • 417 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

1994 • 354 citations

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

1990 • 322 citations

JAK2, a third member of the JAK family of protein tyrosine kinases.

1992 • 306 citations

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

1994 • 304 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

1994 • 209 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Leukemia Inhibitory Factor and Interleukin-6 Trigger the Same Immediate Early Response, Including Tyrosine Phosphorylation, upon Induction of Myeloid Leukemia Differentiation

1991 • 186 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells.

1994 • 162 citations

The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.

1994 • 158 citations

Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.

1991 • 147 citations

Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction

1993 • 138 citations

The interaction of antibody with the major surface glycoprotein of vesicular stornatitis virus II. Monoclonal antibodies to nonneutralizing and cross-reactive epitopes of Indiana and New Jersey serotypes

1982 • 137 citations

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.

1994 • 120 citations

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

1994 • 109 citations

Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.

1994 • 82 citations

[45] Cloning members of protein-tyrosine kinase family using polymerase chain reaction

1991 • 70 citations