Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Cytokine receptor signalling

1995 • 1,242 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Allergy‐associated Iϵ and Fcϵ receptor II (CD23b) genes activated via binding of an interleukin‐4‐induced transcription factor to a novel responsive element

1993 • 121 citations

IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain

1996 • 90 citations

IL-4 requirements for the generation of secondary in vivo IgE responses.

1991 • 71 citations

Interleukin 4 induces membrane Thy-1 expression on normal murine B cells.

1988 • 39 citations

Regulation of the murine Fc epsilon RII (CD23) gene. Functional characterization of an IL-4 enhancer element.

1994 • 30 citations

A novel IL-4 responsive element of the Eα MHC class II promoter that binds to an inducible factor

1995 • 11 citations