Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma.

1987 • 146 citations

Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

1992 • 114 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

1992 • 102 citations

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

1991 • 97 citations

In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

1993 • 92 citations

Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21.

1984 • 91 citations

Generation and characterization of monoclonal antibodies specific for the human IFN-gamma receptor.

1988 • 78 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade.

1993 • 67 citations

Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity.

1992 • 58 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor.

1991 • 50 citations

The mouse immune interferon receptor gene is located on chromosome 10.

1987 • 49 citations

Inactivation of Erythropoietin Receptor Function by Point Mutations in a Region Having Homology with other Cytokine Receptors

1993 • 45 citations

Biosynthetic analysis of the human interferon-γ receptor

1989 • 42 citations

Purification and partial characterization of a receptor protein for mouse interferon gamma.

1988 • 35 citations

Ligand-induced phosphorylation of the human interferon-gamma receptor. Dependence on the presence of a functionally active receptor.

1990 • 31 citations

High affinity human IFN-gamma-binding capacity is encoded by a single receptor gene located in proximity to c-ros on human chromosome region 6q16 to 6q22.

1988 • 31 citations

Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.

1990 • 26 citations

In Vitro Activation of a Transcription Factor by Gamma Interferon Requires a Membrane-Associated Tyrosine Kinase and Is Mimicked by Vanadate

1993 • 18 citations

Construction and analysis of an EMBL‐3 phage library containing partially digested human chromosome 21‐specific DNA inserts (15–20 kb)

1986 • 16 citations

In Vitro Activation of the Transcription Factor Gamma Interferon Activation Factor by Gamma Interferon: Evidence for a Tyrosine Phosphatase/Kinase Signaling Cascade

1993 • 12 citations