The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cytokine receptor signalling

1995 • 1,242 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

1986 • 733 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

1996 • 589 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 • 406 citations

The X-ray structure of a growth hormone–prolactin receptor complex

1994 • 390 citations

Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects

1991 • 377 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

1991 • 286 citations

Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors

1986 • 269 citations

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.

1994 • 242 citations

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

1995 • 220 citations

Novel Fold and Putative Receptor Binding Site of Granulocyte-Macrophage Colony-Stimulating Factor

1991 • 206 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

A Critical Cytoplasmic Domain of the Interleukin-5 (IL-5) Receptor α Chain and Its Function in IL-5-Mediated Growth Signal Transduction

1994 • 139 citations

The integrity of the conserved ‘WS motif’ common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.

1991 • 130 citations

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

1994 • 118 citations

Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

1992 • 112 citations

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.

1992 • 112 citations

Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor

1996 • 111 citations

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

1994 • 105 citations

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

1995 • 103 citations

Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling

1996 • 95 citations

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common β-Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands

1996 • 92 citations

A Model for the Interaction of the GM-CSF, IL-3 and IL-5 Receptors with their Ligands

1993 • 92 citations

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction.

1994 • 91 citations

Double antenna structure of chicken prolactin receptor deduced from the cDNA sequence

1992 • 91 citations

The role of the WSXWS equivalent motif in growth hormone receptor function.

1994 • 91 citations

Human Interleukin-3 (IL-3) Induces Disulfide-Linked IL-3 Receptor α- and β-Chain Heterodimerization, Which Is Required for Receptor Activation but Not High-Affinity Binding

1996 • 88 citations

Mutational analysis of the ligand-binding domain of the prolactin receptor.

1991 • 84 citations

Evidence for a Physical Association between the Shc-PTB Domain and the βc Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor

1996 • 82 citations

Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.

1994 • 81 citations

Chromosomal localization and organization of the murine genes encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors.

1992 • 80 citations

A Membrane-Proximal Region of the Interleukin-2 Receptor γ_c Chain Sufficient for Jak Kinase Activation and Induction of Proliferation in T Cells

1996 • 69 citations

Mutations in the WSAWSE and Cytosolic Domains of the Erythropoietin Receptor Affect Signal Transduction and Ligand Binding and Internalization

1992 • 69 citations

Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits

1993 • 67 citations

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor

1994 • 65 citations

The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.

1994 • 61 citations

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit.

1996 • 59 citations

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1994 • 56 citations

Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor.

1995 • 56 citations

Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.

1995 • 56 citations

Identification of a Critical Ligand Binding Determinant of the Human Erythropoietin Receptor

1996 • 55 citations

Dimer- and Oligomerization of the Erythropoietin Receptor by Disulfide Bond Formation and Significance of the Region Near the WSXWS Motif in Intracellular Transport

1993 • 51 citations

High affinity ligand binding is not essential for granulocyte-macrophage colony-stimulating factor receptor activation.

1992 • 49 citations

A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line.

1994 • 46 citations

The Murine Interleukin-4 Receptor Gene: Genomic Structure, Expression and Potential for Alternative Splicing

1992 • 43 citations

Interacting Residues in the Extracellular Region of the Common β Subunit of the Human Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptors Involved in Constitutive Activation

1996 • 40 citations

High-Affinity Chimeric Human Granulocyte-Macrophage Colony-Stimulating Factor-Receptor Carrying the Cytoplasmic Domain of the β Subunit But Not the α Subunit Transduces Growth-Promoting Signals in Ba/F3 Cells

1995 • 39 citations

Identification of conserved amino acids in the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit critical for function. Evidence for formation of a heterodimeric receptor complex prior to ligand binding.

1994 • 39 citations

Structure of mouse interleukin 3 (IL-3) binding protein (AIC2A). Amino acid residues critical for IL-3 binding.

1992 • 37 citations

Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization.

1992 • 37 citations

Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2.

1992 • 34 citations

Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.

1996 • 33 citations

Cytokine receptors and signal transduction

1994 • 32 citations

Interaction of GM-CSF and IL-3 with the common β-chain of their receptors

1995 • 32 citations

A constitutively activated chimeric cytokine receptor confers factor- independent growth in hematopoietic cell lines

1996 • 31 citations

Evidence for the ligand‐induced conversion from a dimer to a tetramer of the granulocyte colony‐stimulating factor receptor

1994 • 30 citations

Molecular modeling of the GM‐CSF and IL‐3 receptor complexes

1995 • 23 citations

A Discontinuous Eight-Amino Acid Epitope in Human Interleukin-3 Binds the α-Chain of Its Receptor

1996 • 21 citations

The structure and dynamics of the granulocyte macrophage colony-stimulating factor receptor defined by the ternary complex model

1993 • 18 citations

Three conserved motifs in the extracellular domain of the human granulocyte-macrophage colony-stimulating factor receptor subunit are essential for ligand binding and surface expression

1994 • 18 citations

A role for the carboxyl terminus of human granulocyte-macrophage colony-stimulating factor in the binding of ligand to the alpha-subunit of the high affinity receptor.

1994 • 14 citations

Ligand-independent Cell Surface Expression of the Human Soluble Granulocyte-Macrophage Colony-stimulating Factor Receptor α Subunit Depends on Co-expression of the Membrane-associated Receptor β Subunit

1996 • 13 citations

Mutational analysis of the alpha subunit of the human interleukin-3 receptor

1996 • 11 citations

Mapping of Human Granulocyte‐Macrophage‐Colony‐Stimulating‐Factor Domains Interacting with the Human Granulocyte‐Macrophage‐Colony‐Stimulating‐Factor‐Receptor α‐Subunit

1994 • 11 citations

Gene structures of the α subunits of human IL-3 and granulocyte-macrophage colony-stimulating factor receptors: Comparison with the cytokine receptor superfamily

1995 • 8 citations

Homodimeric Murine Interleukin-3 Agonists Indicate that Ligand Dimerization is Important for High-Affinity Receptor Complex Formation

1994 • 7 citations