Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Cytokine receptor signalling

1995 • 1,242 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

1994 • 342 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

Interferons and other regulatory cytokines

1989 • 306 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.

1994 • 224 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

Substrate specificity of the protein tyrosine phosphatases.

1993 • 189 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

1993 • 154 citations

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

1994 • 150 citations

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.

1993 • 112 citations

Interferon-activated signal transduction to the nucleus

1994 • 108 citations

Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling

1995 • 98 citations

In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

1993 • 92 citations

Cytokine triggered molecular pathways that control cell cycle arrest

1992 • 89 citations

Protein Tyrosine Phosphatases: Mechanism of Catalysis and Substrate Specificity

1994 • 88 citations

Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor.

1992 • 84 citations

In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade.

1993 • 67 citations