Stat5 as a Target for Regulation by Extracellular Matrix

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells.

1987 • 591 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

1994 • 354 citations

Expression of extracellular matrix components is regulated by substratum.

1990 • 345 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Extracellular matrix regulates expression of the TGF-beta 1 gene.

1993 • 260 citations

Laminin forms an independent network in basement membranes [published erratum appears in J Cell Biol 1992 Jun;118(2):493]

1992 • 259 citations

Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants.

1994 • 225 citations

Transmembrane signalling by integrins

1992 • 219 citations

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.

1990 • 217 citations

A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.

1992 • 187 citations

Nuclear Factor I and Mammary Gland Factor (STAT5) Play a Critical Role in Regulating Rat Whey Acidic Protein Gene Expression in Transgenic Mice

1995 • 163 citations

Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells.

1994 • 159 citations

Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor

1991 • 137 citations

Position-independent expression of the ovine β-lactoglobulin gene in transgenic mice

1992 • 120 citations

Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

1992 • 116 citations

Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element.

1994 • 92 citations

Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells.

1994 • 82 citations

Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation.

1994 • 81 citations

Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors.

1994 • 70 citations

Signal Transduction: Just another signalling pathway

1994 • 58 citations

The mammary factor MPBF is a prolactin‐induced transcriptional regulator which binds to STAT factor recognition sites

1994 • 53 citations