The ubiquitin‐proteasome pathway and proteasome inhibitors

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The Transcriptional Program of Sporulation in Budding Yeast

1998 • 1,876 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Structure of ubiquitin refined at 1.8 Å resolution

1987 • 1,682 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

1996 • 1,386 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

UBE3A/E6-AP mutations cause Angelman syndrome

1997 • 1,270 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

RING Finger Proteins

2000 • 1,216 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

1997 • 847 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

1997 • 806 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Whose end is destruction: cell division and the anaphase-promoting complex

1999 • 679 citations

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

1998 • 674 citations

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

1999 • 650 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Signaling to p53

1998 • 636 citations

Does this have a familiar RING?

1996 • 632 citations

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1995 • 609 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients

1998 • 558 citations

Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade

1999 • 539 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

1998 • 521 citations

‘Puppet’ Children A Report on Three Cases

1965 • 521 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

Activation of the cell death program by inhibition of proteasome function

1997 • 494 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

The proteasome inhibitor PS-341 in cancer therapy.

1999 • 475 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Universality and Structure of the N-end Rule

1989 • 472 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1995 • 460 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Penicillin acylase has a single-amino-acid catalytic centre

1995 • 448 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

How the Cyclin Became a Cyclin

1999 • 441 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair

2000 • 425 citations

Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP

1999 • 424 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

Regulation of p53 stability

1999 • 413 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation

1997 • 388 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Reconstitution of G ₁ Cyclin Ubiquitination with Complexes Containing SCF ^Grr1 and Rbx1

1999 • 385 citations

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

2000 • 378 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

Angelman syndrome: Consensus for diagnostic criteria

1995 • 368 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Viewpoint: Putting the Cell Cycle in Order

1996 • 357 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

The N‐end rule pathway of protein degradation

1997 • 354 citations

Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα

1999 • 348 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1996 • 340 citations

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

2000 • 334 citations

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

1998 • 330 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1993 • 326 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress

1999 • 320 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway

1991 • 316 citations

Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome

1998 • 312 citations

Proteolysis and the cell cycle: with this RING I do thee destroy

2000 • 308 citations

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

1999 • 308 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation

1999 • 305 citations

A role for ubiquitin ligase recruitment in retrovirus release

2000 • 304 citations

Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex

2000 • 301 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis

1998 • 289 citations

Ubiquitin is part of the retrovirus budding machinery

2000 • 288 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of α‘,β‘-Epoxyketone Proteasome Inhibitors

2000 • 285 citations

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.

1991 • 281 citations

SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

1998 • 271 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

1991 • 268 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

TMC-95A, B, C, and D, Novel Proteasome Inhibitors Produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, Production, Isolation, and Biological Activities.

2000 • 265 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases

1998 • 259 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

Structures of TMC-95A−D: Novel Proteasome Inhibitors from Apiospora montagnei Sacc. TC 1093

2000 • 257 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

1998 • 253 citations

Proteasome Inhibition: a New Strategy in Cancer Treatment

2000 • 252 citations

The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells

1998 • 247 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

1994 • 238 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.

1994 • 225 citations

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

1998 • 219 citations

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells

1997 • 213 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes

1999 • 204 citations

Epoxomicin, a new antitumor agent of microbial origin.

1992 • 202 citations

Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology

1999 • 200 citations

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

2000 • 198 citations

In Vivo Assembly of the Proteasomal Complexes, Implications for Antigen Processing

1995 • 193 citations

Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

1993 • 190 citations

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

2000 • 185 citations

Total Synthesis and Biological Activity of Lactacystin, Omuralide and Analogs.

1999 • 185 citations

Checkpoints: How to activate p53

2000 • 181 citations

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

1999 • 180 citations

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

1998 • 179 citations

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

1998 • 178 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

GSK-3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin

2000 • 177 citations

Three-dimensional structure of human lysosomal aspartylglucosaminidase

1995 • 177 citations

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

1998 • 172 citations

The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination

2000 • 171 citations

SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

2000 • 168 citations

Ubiquitin Is Covalently Attached to the p6 ^Gag Proteins of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus and to the p12 ^Gag Protein of Moloney Murine Leukemia Virus

1998 • 162 citations

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

1999 • 160 citations

Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

1999 • 158 citations

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

1993 • 155 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5

1996 • 151 citations

Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity

1997 • 150 citations

Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones

1999 • 150 citations

Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105

1995 • 150 citations

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

1993 • 149 citations

20 S proteasomes are assembled via distinct precursor complexes processing of LMP2 and LMP7 proproteins takes place in 13–16 S preproteasome complexes

1994 • 146 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Three-dimensional structure of ubiquitin at 2.8 A resolution.

1985 • 140 citations

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

1996 • 139 citations

Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin.

1987 • 138 citations

The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome

1999 • 136 citations

Proteasome Inhibitors Induce Apoptosis in Glucocorticoid-Resistant Chronic Lymphocytic Leukemic Lymphocytes

1998 • 136 citations

The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

1997 • 129 citations

The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

1998 • 126 citations

Human Papillomavirus Type 16 E6 Induces Self-Ubiquitination of the E6AP Ubiquitin-Protein Ligase

2000 • 124 citations

Regulation and function of the p53-related proteins: same family, different rules

2000 • 123 citations

Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors

2001 • 121 citations

Subunit arrangement in the human 20S proteasome

1997 • 121 citations

Lactacystin, a Specific Inhibitor of the Proteasome, Inhibits Human Platelet Lysosomal Cathepsin A-like Enzyme

1997 • 116 citations

Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme.

1991 • 115 citations

Sequential 1H NMR Assignments and Secondary Structure Identification of Human Ubiquitin

1987 • 114 citations

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

1994 • 112 citations

Towards a molecular understandingof Prader-Willi and Angelman syndromes

1999 • 103 citations

Bivalency as a principle for proteasome inhibition

1999 • 102 citations

Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.

1995 • 99 citations

Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast

1997 • 98 citations

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

1990 • 98 citations

Sequential proton NMR assignments and secondary structure identification of human ubiquitin

1987 • 97 citations

Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production

2000 • 96 citations

Role of the proteasome in Alzheimer’s disease

2000 • 95 citations

Comparison of the Effect of Calpain Inhibitors on Two Extralysosomal Proteinases: The Multicatalytic Proteinase Complex and m‐Calpain

1994 • 89 citations

N-recognin/Ubc2 interactions in the N-end rule pathway

1993 • 88 citations

NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway

1998 • 86 citations

Ubiquitin in avian leukosis virus particles

1990 • 85 citations

The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation.

1993 • 82 citations

Culprits in the degradation of cyclin E apprehended

1999 • 81 citations

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)

1991 • 81 citations

PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity

1994 • 80 citations

Multiple forms of ubiquitin-activating enzyme E1 from wheat. Identification of an essential cysteine by in vitro mutagenesis.

1992 • 78 citations

Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits

1994 • 76 citations

Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei

1999 • 72 citations

Sodium Dodecyl Sulfate (SDS) Activation of the 20S Proteasome in Rat Liver

1995 • 70 citations

Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes

1999 • 69 citations

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehydes (glyoxals)

1998 • 66 citations

Enzymes Catalyzing Ubiquitination and Proteolytic Processing of the p105 Precursor of Nuclear Factor κB1

1998 • 65 citations

Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines.

1995 • 64 citations

Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.

1998 • 63 citations

The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum.

1996 • 63 citations

Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome

1997 • 61 citations

Stable ester conjugate between the Saccharomyces cerevisiae RAD6 protein and ubiquitin has no biological activity

1991 • 58 citations

Identification of Determinants in E2 Ubiquitin-conjugating Enzymes Required for hect E3 Ubiquitin-Protein Ligase Interaction

1999 • 57 citations

Synthetic Inhibitors of the Multicatalytic Proteinase Complex (Proteasome)

1993 • 55 citations

Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex

1991 • 53 citations

The proteasome from Thermoplasma acidophilum is neither a cysteine nor a serine protease

1995 • 51 citations

Design and synthesis of novel protease inhibitors. Tripeptide α′,β′-epoxyketones as nanomolar inactivators of the proteasome

1996 • 50 citations

Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation.

1996 • 50 citations

Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/β-lactone is not a specific inhibitor of the proteasome

2000 • 49 citations

In vitro Activation of the 20S Proteasome

1993 • 49 citations

cDNA cloning and sequencing of component C5 of proteasomes from rat hepatoma cells

1990 • 48 citations

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone

1998 • 47 citations

Potent α-ketocarbonyl and boronic ester derived inhibitors of proteasome

1996 • 45 citations

Catalytic Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome)

1993 • 44 citations

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides

1998 • 38 citations

Alzheimer's Disease-Linked Mutation of Presenilin 2 (N141I-PS2) Drastically Lowers APPα Secretion: Control by the Proteasome

1998 • 35 citations

High Performance Computing in Chemistry

1998 • 34 citations

Mutational analysis of subunit iβ2 (MECL‐1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes

1999 • 33 citations

P′-extended α-ketoamide inhibitors of proteasome

1999 • 31 citations

Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome) Cleaving Bonds after Hydrophobic Residues

1999 • 30 citations

TMC-86A, B and TMC-96, New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. II. Physico-chemical Properties and Structure Determination.

2000 • 26 citations

TMC-89A and B, New Proteasome Inhibitors from Streptomyces sp. TC 1087.

2000 • 22 citations

Affinity labeling and localization of the ATP binding site in the (Na+,K+)-ATPase.

1983 • 19 citations

Deleted Work

1955 • 0 citations