Universality and Structure of the N-end Rule

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure

1987 • 508 citations

The yeast ubiquitin genes: a family of natural gene fusions.

1987 • 500 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

The degradation signal in a short-lived protein

1989 • 427 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

[29] Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli

1987 • 392 citations

IN VITRO MUTAGENESIS

1985 • 338 citations

Sequence determinants of cytosolic N-terminal protein processing

1986 • 304 citations

The ubiquitin system: functions and mechanisms

1985 • 298 citations

Molecular analysis of a cell lineage

1983 • 286 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

One-step purification of hybrid proteins which have β-galactosidase activity

1984 • 265 citations

Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase.

1985 • 239 citations

Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation

1987 • 224 citations

The Ubiquitin Pathway for the Degradation of Intracellular Proteins

1986 • 213 citations

Protein degradation in E. coli: The ion mutation and bacteriophage lambda N and cll protein stability

1981 • 208 citations

Specificity of cotranslational amino-terminal processing of proteins in yeast

1987 • 204 citations

Cotranslational processing and protein turnover in eukaryotic cells

1988 • 201 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Role of arginine-tRNA in protein degradation by the ubiquitin pathway

1987 • 142 citations

Soluble Amino Acid-incorporating System

1965 • 140 citations

Enzymatic deamidation of methyl-accepting chemotaxis proteins in Escherichia coli catalyzed by the cheB gene product.

1983 • 138 citations

The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes.

1988 • 133 citations

Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin.

1988 • 123 citations

Sites of methyl esterification and deamination on the aspartate receptor involved in chemotaxis.

1984 • 108 citations

N-terminal methionine-specific peptidase in Salmonella typhimurium.

1987 • 106 citations

Ribosomal protein synthesis is not regulated at the translational level in Saccharomyces cerevisiae: balanced accumulation of ribosomal proteins L16 and rp59 is mediated by turnover of excess protein.

1988 • 100 citations

hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein

1986 • 98 citations

The accumulation of three yeast ribosomal proteins under conditions of excess mRNA is determined primarily by fast protein decay.

1988 • 90 citations

Transfer RNA is required for conjugation of ubiquitin to selective substrates of the ubiquitin- and ATP-dependent proteolytic system.

1986 • 77 citations

Induction of the heat shock response of E. coli through stabilization of sigma 32 by the phage lambda cIII protein.

1987 • 76 citations

Handbook of Protein Sequence Analysis

1981 • 62 citations

Rapid intracellular turnover of adenovirus 5 early region 1A proteins

1984 • 62 citations

Incorporation of 3H-amino acids into proteins in a partially purified fraction of axoplasm: evidence for transfer RNA-mediated, post- translational protein modification in squid giant axons

1983 • 61 citations

Tobacco mosaic virus particles contain ubiquitinated coat protein subunits

1988 • 58 citations

Ubiquitin carrier protein-catalyzed ubiquitin transfer to histones. Mechanism and specificity.

1988 • 49 citations

Protein Modification by Amino Acid Addition Is Increased in Crushed Sciatic But Not Optic Nerves

1986 • 43 citations

[18] Aminoacyl-tRNA: Protein transferases

1984 • 20 citations

A class of Escherichia coli proteins controlled by the hflA locus

1987 • 20 citations