Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology

1996 • 478 citations

The multicatalytic and 26 S proteases.

1993 • 476 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

1997 • 367 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

1996 • 229 citations

Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein

1997 • 216 citations

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells

1997 • 213 citations

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

1996 • 203 citations

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ₄₂₍₄₃₎

1996 • 183 citations

Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol

1996 • 172 citations

The Multicatalytic Proteinase

1989 • 145 citations

Evidence for phosphorylation and oligomeric assembly of presenilin 1

1997 • 145 citations

Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases

1997 • 138 citations

Aβ40 is a major form of β-amyloid in nonhuman primates

1996 • 112 citations

The functional basis of ocular dominance: functional MRI (fMRI) findings

1996 • 109 citations

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C

1997 • 107 citations

Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS.

1996 • 88 citations

Intracellular Production of .beta.A4 Amyloid of Alzheimer's Disease: Modulation by Phosphoramidon and Lack of Coupling to the Secretion of the Amyloid Precursor Protein

1995 • 80 citations

α‐Secretase‐Derived Product of β‐Amyloid Precursor Protein Is Decreased by Presenilin 1 Mutations Linked to Familial Alzheimer's Disease

1997 • 66 citations

Amyloid (Aβ) deposition in chromosome 1–linked Alzheimer's disease: The volga german families

1997 • 55 citations

Presenile because of presenilin

1996 • 50 citations

Proteasome Contributes to the α‐Secretase Pathway of Amyloid Precursor Protein in Human Cells

1997 • 47 citations

Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions

1992 • 41 citations

Constitutive and Protein Kinase C‐Regulated Secretory Cleavage of Alzheimer's β‐Amyloid Precursor Protein: Different Control of Early and Late Events by the Proteasome

1997 • 41 citations

Protein Kinase A Phosphorylation of the Proteasome: A Contribution to the α‐Secretase Pathway in Human Cells

1996 • 37 citations

Examination of the role of endopeptidase 3.4.24.15 in Aβ secretion by human transfected cells

1997 • 36 citations

Lactacystin, an Inhibitor of the Proteasome, Blocks the Degradation of a Mutant Precursor of Glycosylphosphatidylinositol-Linked Protein in a Pre-Golgi Compartment

1996 • 30 citations

Presenilin–1 is Processed into Two Major Cleavage Products in Neuronal Cell Lines

1996 • 29 citations

Specific transcellular binding between membrane proteins crucial to Alzheimer disease.

1996 • 27 citations

Lack of effect of Presenilin 1, βAPP and their Alzheimer's disease-related mutated forms on Xenopus oocytes membrane currents

1997 • 9 citations