Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

1998 • 674 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Arthritis in rats after systemic injection of streptococcal cells or cell walls.

1977 • 437 citations

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

1995 • 389 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Activation of the transcription factor nuclear factor‐κB in human inflamed synovial tissue

1996 • 314 citations

Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis

1982 • 304 citations

Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65

1995 • 289 citations

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

1988 • 246 citations

Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes

1995 • 167 citations

Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.

1997 • 164 citations

Kinetic Characterization of the Chymotryptic Activity of the 20S Proteasome

1996 • 137 citations

New insights into proteasome function: from archaebacteria to drug development

1995 • 136 citations

Genes for SMA: Multum in parvo

1995 • 121 citations

Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis.

1997 • 116 citations

Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.

1994 • 116 citations

Characteristics of tumor necrosis factor production in rheumatoid arthritis

1989 • 115 citations

Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls

1979 • 102 citations

A simple, sensitive bioassay for the detection of interleukin-1 using human melanoma A375 cell line

1988 • 99 citations

Measurement of Nitrate and Nitrite in Extracellular Fluids: A Window to Systemic Nitric Oxide Metabolism

1995 • 83 citations

The pathogenesis of group a streptococcal cell wall‐induced polyarthritis in the rat comparative studies in arthritis resistant and susceptible inbred rat strains

1983 • 79 citations

Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells.

1998 • 76 citations

Chapter 28. Novel Inhibitors of the Proteasome and Their Therapeutic Use in Inflammation

1996 • 67 citations

Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production

1998 • 64 citations

Role of the Rho GTPase in Bradykinin-Stimulated Nuclear Factor-κB Activation and IL-1β Gene Expression in Cultured Human Epithelial Cells

1998 • 56 citations

Effect of iron complexes on adjuvant arthritis in rats.

1992 • 19 citations

Novel Approaches for the Treatment of Inflammatory Diseases: Inhibitors of NF-KB and AP-1

1997 • 12 citations

Soluble factors and solid phases

1992 • 9 citations