The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Fungal infections in cancer patients: An international autopsy survey

1992 • 556 citations

Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells

1995 • 540 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

The inducible transcription factor NF-κB: structure-function relationship of its protein subunits

1993 • 429 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.

1994 • 266 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

1994 • 217 citations

Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.

1992 • 197 citations

Favorable outcome of invasive aspergillosis in patients with acute leukemia.

1987 • 190 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

Immunosuppression in vitro by a metabolite of a human pathogenic fungus.

1984 • 178 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi

1994 • 173 citations

The emergence of fungi as major hospital pathogens

1988 • 163 citations

Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties.

1988 • 155 citations

Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.

1995 • 139 citations

The effect of gliotoxin upon macrophage function

1986 • 125 citations

Interleukin 2 signaling involves the phosphorylation of Stat proteins.

1995 • 124 citations

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

1988 • 116 citations

Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity

1986 • 106 citations

Multiple kinases mediate T-cell-receptor signalling

1995 • 96 citations

Gliotoxin causes oxidative damage to plasmid and cellular DNA.

1988 • 89 citations

Apoptosis induced in macrophages and T blasts by the mycotoxin sporidesmin and protection by Zn2+ salts

1990 • 70 citations

NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction

1995 • 66 citations

Cyclosporin A Clinical Pharmacology and Therapeutic Potential

1982 • 56 citations

The immunomodulating agent gliotoxin causes genomic DNA fragmentation

1987 • 54 citations

The RxxRxRxxC Motif Conserved in All Rel/κΒ Proteins Is Essential for the DNA-Binding Activity and Redox Regulation of the v-Rel Oncoprotein

1992 • 51 citations

The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences.

1991 • 51 citations

A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.

1993 • 47 citations

Lack of correlation between early intracellular calcium ion rises and the onset of apoptosis in thymocytes

1994 • 44 citations

Gliotoxin Stimulates Ca2+ Release from Intact Rat Liver Mitochondria

1994 • 44 citations

Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins

1995 • 39 citations

Sporidesmins. Part X. Synthesis of polysulphides by reaction of dihydrogen disulphide with disulphides and thiols

1970 • 22 citations

Immunosuppression in renal transplantation

1982 • 4 citations