Three-dimensional structure of human lysosomal aspartylglucosaminidase

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

A visual protein crystallographic software system for X11/Xview

1992 • 552 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Penicillin acylase has a single-amino-acid catalytic centre

1995 • 448 citations

Atomic features of protein-carbohydrate interactions

1991 • 305 citations

Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.

1993 • 294 citations

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

1993 • 269 citations

ASPARTYLGLYCOSAMINURIA

1968 • 266 citations

Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis

1994 • 235 citations

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.

1993 • 161 citations

Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease.

1991 • 139 citations

Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex

1995 • 94 citations

A left‐handed crossover involved in amidohydrolase catalysis

1993 • 82 citations

Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline.

1991 • 72 citations

Lysosomal aspartylglucosaminidase is processed to the active subunit complex in the endoplasmic reticulum.

1993 • 68 citations

Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation

1993 • 64 citations

SQUASH – combining constraints for macromolecular phase refinement and extension

1993 • 60 citations

Spectrum of mutations in aspartylglucosaminuria.

1991 • 58 citations

The isolation and characterisation of a cDNA clone encoding L-asparaginase from developing seeds of lupin (Lupinus arboreus)

1992 • 49 citations

The three-dimensional structure of PNGase F, a glycosyl asparaginase from Flavobacterium meningosepticum

1994 • 46 citations

Intracellular Sorting of Aspartylglucosaminidase: The Role ofN-Linked Oligosaccharides and Evidence of Man-6-P-Independent Lysosomal Targeting

1995 • 40 citations

In vitro mutagenesis helps to unravel the biological consequences of aspartylglucosaminuria mutation

1991 • 39 citations

Molecular Cloning and Sequence Analysis of Flavobacterium meningosepticum Glycosylasparaginase: A Single Gene Encodes the α and β Subunits

1995 • 38 citations

Substrate specificity and reaction mechanism of human glycoasparaginase. The N-glycosidic linkage of various glycoasparagines is cleaved through a reaction mechanism similar to L-asparaginase.

1992 • 37 citations

Molecular Cloning, Chromosomal Assignment, and Expression of the Mouse Aspartylglucosaminidase Gene

1995 • 36 citations

Crystal Structure of Peptide-N4-(N-acetyl-.beta.-D-glucosaminyl)asparagine amidase F at 2.2-.ANG. Resolution

1994 • 30 citations

Targeting of Proteins to the Lysosome

1991 • 30 citations

Immediate Interaction between the Nascent Subunits and Two Conserved Amino Acids Trp34 and Thr206 Are Needed for the Catalytic Activity of Aspartylglucosaminidase

1995 • 29 citations

Post‐translational processing and Thr‐206 are required for glycosylasparaginase activity

1993 • 23 citations

Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex.

1995 • 22 citations

Genomic structure of human lysosomal glycosylasparaginase

1991 • 18 citations

Large-scale purification and preliminary X-ray diffraction studies of glycosylated human aspartylglucosaminidase

1996 • 2 citations