The multicatalytic proteinase complex, a major extralysosomal proteolytic system

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)

1988 • 404 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.

1986 • 327 citations

Cation‐Sensitive Neutral Endopeptidase: Isolation and Specificity of the Bovine Pituitary Enzyme

1980 • 313 citations

Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function

1986 • 290 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria

1989 • 277 citations

A soluble metalloendopeptidase from rat brain

1983 • 270 citations

Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.

1987 • 255 citations

ATP-dependent degradation of ubiquitin-protein conjugates.

1984 • 248 citations

Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.

1985 • 244 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

THE RELEASE OF LABELED AMINO ACIDS FROM THE PROTEINS OF RAT LIVER SLICES

1953 • 236 citations

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.

1984 • 232 citations

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

1985 • 231 citations

Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.

1988 • 225 citations

Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle

1985 • 208 citations

Leucylglycinamide Released from Oxytocin by Human Uterine Enzyme

1971 • 208 citations

Activation of the multicatalytic proteinase from rat skeletal muscle by fatty acids or sodium dodecyl sulphate

1985 • 184 citations

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

1988 • 179 citations

Involvement of the proteasome in various degradative processes in mammalian cells.

1989 • 162 citations

Electron microscopy and image analysis of the multicatalytic proteinase

1988 • 150 citations

Identification and partial purification of an ATP-stimulated alkaline protease in rat liver.

1979 • 149 citations

The Multicatalytic Proteinase

1989 • 145 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system

1987 • 132 citations

Alterations in the extracellular domain of M13 procoat protein make its membrane insertion dependent on secA and secY

1988 • 128 citations

The Drosophila proteasome undergoes changes in its subunit pattern during development

1989 • 127 citations

A multicatalytical protease complex from pituitary that forms enkephalin and enkephalin containing peptides

1981 • 122 citations

Prosomes

1986 • 122 citations

Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides

1989 • 117 citations

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

1989 • 115 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes

1986 • 107 citations

Eukaryotic pre-tRNA 5′ processing nuclease: Copurification with a complex cylindrical particle

1986 • 106 citations

Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin.

1989 • 93 citations

Purification of neutral lens endopeptidase: close similarity to a neutral proteinase in pituitary.

1985 • 93 citations

Half-life of proteasomes (multiprotease complexes) in rat liver

1989 • 87 citations

Molecular cloning of cDNA for proteasomes (multicatalytic proteinase complexes) from rat liver: primary structure of the largest component (C2)

1989 • 86 citations

Molecular organization of a high molecular weight multi-protease complex from rat liver

1988 • 83 citations

Proteolysis in eukaryotic cells. Proteinase yscE, a new yeast peptidase.

1984 • 76 citations

Molecular cloning of cDNA for proteasomes from rat liver: primary structure of component C3 with a possible tyrosine phosphorylation site

1990 • 73 citations

Size and shape of the multicatalytic proteinase from rat skeletal muscle

1986 • 73 citations

A 20S particle ubiquitous from yeast to human

1987 • 67 citations

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

1990 • 67 citations

Proteinase yscE of yeast shows homology with the 20 S cylinder particles of Xenopus laevis

1988 • 66 citations

Analysis of cytoplasmic 19 S ring-type particles in Drosophila which contain hsp 23 at normal growth temperature

1985 • 63 citations

CYTOPLASMIC PARTICLES AND AMINOACYL TRANSFERASE I ACTIVITY

1970 • 61 citations

ATP-stimulated proteolysis in soluble extracts of BHK 21C13 cells

1988 • 60 citations

Sea urchin prosome: characterization and changes during development.

1987 • 59 citations

Purification and characterization of a multicatalytic proteinase from crustacean muscle: Comparison of latent and heat-activated forms

1989 • 58 citations

Subcellular Distribution of Prolyl Endopeptidase and Cation‐Sensitive Neutral Endopeptidase in Rabbit Brain

1982 • 57 citations

Effects of temperature on the degradation of proteins in rabbit reticulocyte lysates and after injection into HeLa cells.

1984 • 56 citations

A high molecular weight protease in the cytosol of rat liver. II. Properties of the purified enzyme.

1986 • 56 citations

Involvement of proteasomes (multicatalytic proteinase) in ATP‐dependent proteolysis in rat reticulocyte extracts

1988 • 54 citations

Metal-dependent proteinase of the lens. Assay, purification and properties of the bovine enzyme

1975 • 52 citations

An ATP‐dependent protease and ingensin, the multicatalytic proteinase, in K562 cells

1988 • 49 citations

The quaternary structure of carp muscle alkaline protease

1980 • 46 citations

The 19S ring-type particles of Drosophila

1987 • 46 citations

Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease.

1986 • 44 citations

Identification and partial purification of a cation-sensitive neutral endopeptidase from bovine pituitaries

1979 • 42 citations

Separation of yeast proteasome subunits

1989 • 40 citations

Sodium dodecyl sulfate-induced conformational and enzymatic changes of multicatalytic proteinase

1989 • 39 citations

An enzyme related to the high molecular weight multicatalytic proteinase, macropain, participates in a ubiquitin-mediated, ATP-stimulated proteolytic pathway in soluble extracts of BHK 21/C13 fibroblasts

1988 • 36 citations

Multicatalytic proteinase in fish muscle

1988 • 36 citations

Structural organization of the multienzyme complex of mammalian aminoacyl-tRNA synthetases

1988 • 34 citations

The latent form of macropain (high molecular weight multicatalytic protease) restores ATP-dependent proteolysis to soluble extracts of BHK fibroblasts pretreated with anti-macropain antibodies

1989 • 32 citations

RNA degrading activity is tightly associated with the multicatalytic proteinase, ingensin

1989 • 30 citations

A multicatalytic high-molecular-weight neutral endopeptidase from human kidney

1987 • 30 citations

A high-molecular-mass neutral endopeptidase-24.5 from human lung

1987 • 28 citations

Donut-shaped “miniparticles” in nuclei of human and rat cells

1982 • 25 citations

Comparative studies on lens neutral endopeptidase and pituitary neutral proteinase: two closely similar enzymes

1986 • 25 citations

Multicatalytic proteinase complex or multicatalytic proteinase: a high-Mr endopeptidase

1988 • 22 citations

The bovine lens neutral proteinase comprises a family of cysteine-dependent proteolytic activities

1986 • 22 citations

Autodegradation of rat liver proteasomes (large multicatalytic proteinase complexes)

1989 • 21 citations

Regulation of the ubiquitin‐mediated proteolytic pathway: Role of the substrate α‐NH₂ group and of transfer RNA

1987 • 19 citations

High-molecular-mass proteinases in rabbit reticulocytes: the multicatalytic proteinase is an ATP-independent enzyme and ATP-activated proteolysis is in part associated with a cysteine proteinase complexed toα1-macroglobulin

1989 • 16 citations

Lens neutral endopeptidase occurs in other bovine and human tissues

1987 • 16 citations

The presence of ATP + ubiquitin-dependent proteinase and multicatalytic proteinase complex in bovine brain

1989 • 15 citations

Inactivation of fructose-1,6-bisphosphate aldolase by cathepsin L stimulation by ATP

1984 • 14 citations

Localization of ingensin in rat central nervous system and skeletal muscle

1988 • 14 citations

Addition of ATP increases the apparent molecular mass of the multicatalytic proteinase, ingensin

1989 • 13 citations

Differential inhibition of two proteolytic activities in bovine lens neutral-proteinase preparations

1985 • 13 citations

Na⁺, K⁺‐specific inhibition of protein and peptide hydrolyses by proteasomes from human hepatoma tissues

1989 • 10 citations

Lens Neutral Proteinase

2015 • 10 citations

ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteineproteinase-α1-macroglobulin complex

1989 • 10 citations