Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

The Behavior and Significance of Slow‐Binding Enzyme Inhibitors

1988 • 828 citations

Current protocols in protein science

1996 • 473 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

Regel zur Abschätzung der chemischen Verschiebung von Protonen an einer Doppelbindung

1966 • 292 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

1996 • 139 citations

Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.

1995 • 99 citations

The LMP antigens: A stable MHC-controlled multisubunit protein complex

1986 • 93 citations

Design and synthesis of novel protease inhibitors. Tripeptide α′,β′-epoxyketones as nanomolar inactivators of the proteasome

1996 • 50 citations

A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex

1992 • 50 citations

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone

1998 • 47 citations

Potent α-ketocarbonyl and boronic ester derived inhibitors of proteasome

1996 • 45 citations

Reactions of [¹⁴C]-3,4-Dichloroisocoumarin with Subunits of Pituitary and Spleen Multicatalytic Proteinase Complexes (Proteasomes)

1997 • 37 citations

A comparative study of the chymotrypsin-like activity of the rat liver multicatalytic proteinase and the ClpP from Escherichia coli.

1993 • 35 citations

Structure and Function of the 20S Proteasome and of Its Regulatory Complexes

1995 • 31 citations

ChemInform Abstract: Design and Synthesis of Novel Protease Inhibitors. Tripeptide α′, β′‐Epoxyketones as Nanomolar Inactivators of the Proteasome.

1996 • 13 citations