β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

LEF-1, a Nuclear Factor Coordinating Signaling Inputs from wingless and decapentaplegic

1997 • 450 citations

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

1998 • 441 citations

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1998 • 395 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis

1996 • 318 citations

LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 Promoter

1997 • 244 citations

Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells.

1997 • 227 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Identification of connexin43 as a functional target for Wnt signalling

1998 • 214 citations

PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint

1993 • 165 citations

Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.

1997 • 119 citations

Transcriptional control of lymphoid development: lessons from gene targeting

1996 • 97 citations

Elimination of Cyclin D1 in Vertebrate Cells Leads to an Altered Cell Cycle Phenotype, Which Is Rescued by Overexpression of Murine Cyclins D1, D2, or D3 but Not by a Mutant Cyclin D1

1997 • 48 citations