TMC-89A and B, New Proteasome Inhibitors from Streptomyces sp. TC 1087.

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

TMC-95A, B, C, and D, Novel Proteasome Inhibitors Produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, Production, Isolation, and Biological Activities.

2000 • 265 citations

Structures of TMC-95A−D: Novel Proteasome Inhibitors from Apiospora montagnei Sacc. TC 1093

2000 • 257 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

c-Fos Degradation by the Proteasome

1998 • 66 citations

Proton NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of "enkephalinase" inhibitors. Relationships between stereochemistry and enzyme recognition

1986 • 46 citations

TMC-86A, B and TMC-96, New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. I. Taxonomy, Fermentation, Isolation, and Biological Activities.

1999 • 38 citations

ChemInform Abstract: TMC‐86A (I), B (II), and TMC‐96 (III), New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. Part 2. Physicochemical Properties and Structure Determination.

2000 • 7 citations