Transcriptional Regulation of Metabolism

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

Coordination of circadian timing in mammals

2002 • 4,132 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome

2000 • 2,695 citations

Type 2 diabetes: principles of pathogenesis and therapy

2005 • 2,509 citations

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

2005 • 2,323 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Transcriptional regulation of adipogenesis

2000 • 1,875 citations

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

2000 • 1,801 citations

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

2001 • 1,782 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

1999 • 1,589 citations

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

CCAAT/enhancer-binding proteins: structure, function and regulation

2002 • 1,355 citations

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

2001 • 1,351 citations

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

2003 • 1,350 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria

1999 • 1,281 citations

Glucose tolerance and mortality: comparison of WHO and American Diabetic Association diagnostic criteria

1999 • 1,271 citations

Molecular Regulation of Adipogenesis

2000 • 1,268 citations

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

2003 • 1,260 citations

Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2002 • 1,249 citations

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

2000 • 1,228 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

Regulation of Muscle Fiber Type and Running Endurance by PPARδ

2004 • 1,050 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

1999 • 1,009 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation

2001 • 969 citations

Rheb Binds and Regulates the mTOR Kinase

2005 • 957 citations

Crucial Step in Cholesterol Homeostasis

2002 • 945 citations

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

2003 • 944 citations

A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

1999 • 931 citations

Impaired Energy Homeostasis in C/EBPα Knockout Mice

1995 • 925 citations

Metabolic Syndrome and Development of Diabetes Mellitus: Application and Validation of Recently Suggested Definitions of the Metabolic Syndrome in a Prospective Cohort Study

2002 • 915 citations

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 • 913 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

2004 • 856 citations

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

2002 • 822 citations

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

2003 • 811 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 805 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

2001 • 784 citations

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene

1997 • 776 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors

2002 • 745 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

THE GLUCOSE-FATTY ACID CYCLE

1981 • 734 citations

Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

2003 • 733 citations

A Web of Circadian Pacemakers

2002 • 732 citations

Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

2000 • 731 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

2004 • 721 citations

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

2003 • 708 citations

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

2001 • 695 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1996 • 654 citations

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

2002 • 653 citations

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

2001 • 647 citations

Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)

2000 • 641 citations

Liver X Receptor Signaling Pathways in Cardiovascular Disease

2003 • 634 citations

Nuclear Receptors and the Control of Metabolism

2003 • 631 citations

A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size

2004 • 618 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

2000 • 605 citations

Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression

2002 • 603 citations

Control of cell number byDrosophilaFOXO: downstream and feedback regulation of the insulin receptor pathway

2003 • 596 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

2001 • 591 citations

Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?

2001 • 587 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Transcriptional Coactivator Complexes

2001 • 569 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks

2002 • 566 citations

The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

2003 • 562 citations

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

2003 • 561 citations

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

2001 • 549 citations

Regulation of gene expression by insulin

1996 • 543 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 534 citations

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver

2004 • 527 citations

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

2003 • 525 citations

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

2001 • 523 citations

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.

1998 • 523 citations

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

2003 • 523 citations

Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome.

2002 • 519 citations

Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

2000 • 518 citations

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

2001 • 510 citations

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

2003 • 509 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

Peroxisome proliferator‐activated receptor δ controls muscle development and oxydative capability

2003 • 497 citations

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

2003 • 491 citations

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

2003 • 490 citations

Muscle-specific Pparg deletion causes insulin resistance

2003 • 487 citations

Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

2003 • 482 citations

Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles

2002 • 474 citations

TOR Regulates Ribosomal Protein Gene Expression via PKA and the Forkhead Transcription Factor FHL1

2004 • 468 citations

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

2001 • 468 citations

Dispensable and Indispensable Amino Acids for Humans

2000 • 466 citations

Rat PPARs: Quantitative Analysis in Adult Rat Tissues and Regulation in Fasting and Refeeding

2001 • 463 citations

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

2002 • 460 citations

Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

2005 • 460 citations

PKC-θ knockout mice are protected from fat-induced insulin resistance

2004 • 459 citations

Deactivation of peroxisome proliferator–activated receptor-α during cardiac hypertrophic growth

2000 • 452 citations

Integrative physiology of human adipose tissue

2003 • 449 citations

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

2004 • 440 citations

Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression

2004 • 429 citations

The Many Forks in FOXO's Road

2003 • 425 citations

Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism

1999 • 424 citations

Nonalcoholic fatty liver disease and the metabolic syndrome

2005 • 423 citations

Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma.

2001 • 418 citations

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

2002 • 415 citations

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

2003 • 410 citations

Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice

2002 • 405 citations

NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells.

1990 • 404 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

1995 • 400 citations

Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription

2002 • 395 citations

Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains

2000 • 394 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

2004 • 388 citations

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

2005 • 379 citations

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

2002 • 378 citations

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks

2000 • 377 citations

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

2003 • 375 citations

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver

2003 • 375 citations

PKC-θ knockout mice are protected from fat-induced insulin resistance

2004 • 373 citations

Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver

1998 • 369 citations

The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells

2003 • 369 citations

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

1995 • 368 citations

A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation

2000 • 365 citations

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

2002 • 365 citations

Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse

2004 • 365 citations

Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

2001 • 364 citations

Pathophysiology and Pharmacological Treatment of Insulin Resistance*

2000 • 354 citations

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.

1993 • 351 citations

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 • 348 citations

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

1999 • 343 citations

Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors

2003 • 334 citations

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

2001 • 328 citations

Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

1995 • 326 citations

Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.

1992 • 324 citations

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

2001 • 318 citations

Autoregulation of the Human Liver X Receptor α Promoter

2001 • 318 citations

The HIV Protease Inhibitor Indinavir Impairs Sterol Regulatory Element-Binding Protein-1 Intranuclear Localization, Inhibits Preadipocyte Differentiation, and Induces Insulin Resistance

2001 • 318 citations

The insulin signalling pathway

2002 • 315 citations

Activation of PPARδ alters lipid metabolism in db/db mice

2000 • 313 citations

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

2004 • 311 citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

1999 • 309 citations

Regulation of the activity of the pyruvate dehydrogenase complex

2002 • 305 citations

The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling

2002 • 305 citations

Regulation of gene expression by SREBP and SCAP

2000 • 305 citations

Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids

2002 • 297 citations

Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.

1996 • 288 citations

Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes

2002 • 288 citations

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

2001 • 288 citations

Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat

1997 • 286 citations

Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

2003 • 285 citations

Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting.

1999 • 281 citations

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

2004 • 279 citations

PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?

2003 • 278 citations

Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression

2002 • 278 citations

Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2

1996 • 274 citations

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

2001 • 271 citations

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

2001 • 271 citations

A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity

2001 • 270 citations

Glucose Regulation of Gene Transcription

2000 • 265 citations

Electrophysiology of the pancreas.

1987 • 259 citations

CYCLIC AMP SIGNALING AND GENE REGULATION

1998 • 257 citations

Reactivation of Peroxisome Proliferator-activated Receptor α Is Associated with Contractile Dysfunction in Hypertrophied Rat Heart

2001 • 255 citations

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

2000 • 254 citations

ATF4 Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene

2002 • 253 citations

p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α

2001 • 253 citations

Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin

2002 • 249 citations

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

2004 • 246 citations

Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism

2002 • 242 citations

The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression

2000 • 236 citations

PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

2001 • 235 citations

Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat

1997 • 235 citations

Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

2000 • 226 citations

PPARα governs glycerol metabolism

2004 • 226 citations

G<scp>UGULIPID</scp>: A Natural Cholesterol-Lowering Agent

2003 • 220 citations

Extrapancreatic insulin-producing cells in multiple organs in diabetes

2004 • 213 citations

PPARγ-mediated insulin sensitization: the importance of fat versus muscle

2005 • 213 citations

A New Selective Peroxisome Proliferator-Activated Receptor γ Antagonist with Antiobesity and Antidiabetic Activity

2002 • 211 citations

Increased Hepatobiliary and Fecal Cholesterol Excretion upon Activation of the Liver X Receptor Is Independent of ABCA1

2002 • 209 citations

Regulation and mechanisms of macrophage cholesterol efflux

2002 • 208 citations

PPARα governs glycerol metabolism

2004 • 206 citations

The peroxisome proliferator‐activated receptor α regulates amino acid metabolism

2001 • 204 citations

In vivo activation of PPAR target genes by RXR homodimers

2004 • 199 citations

Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c

2005 • 196 citations

Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter

2000 • 195 citations

Insulin-regulated gene expression

2001 • 193 citations

Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle

2003 • 192 citations

Differential Regulation of Rat and HumanCYP7A1by the Nuclear Oxysterol Receptor Liver X Receptor-α

2003 • 190 citations

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

1993 • 190 citations

Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB

2003 • 187 citations

Cross-Talk between Fatty Acid and Cholesterol Metabolism Mediated by Liver X Receptor-α

2000 • 187 citations

Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients

2003 • 186 citations

Nuclear receptor regulation of cholesterol and bile acid metabolism

1999 • 185 citations

The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor γ and Its Therapeutic Modulation

2003 • 184 citations

Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes

2005 • 181 citations

Effect of endurance training on lipid metabolism in women: a potential role for PPARα in the metabolic response to training

2000 • 181 citations

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

2003 • 181 citations

Disruption of the c/ebpα Gene in Adult Mouse liver

1997 • 180 citations

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

2002 • 179 citations

Glutamine and Cancer

2001 • 178 citations

Regulation and mechanisms of macrophage cholesterol efflux

2002 • 177 citations

Retinoid X receptors are essential for early mouse development and placentogenesis

1999 • 176 citations

Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

1996 • 173 citations

Expression of the Insulin-responsive Glucose Transporter GLUT4 in Adipocytes Is Dependent on Liver X Receptor α

2003 • 173 citations

PPARs: Transcription Factors Controlling Lipid and Lipoprotein Metabolism

2002 • 172 citations

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ER ^T2 ) in adipocytes

2000 • 171 citations

Pathophysiology and Pharmacological Treatment of Insulin Resistance

2000 • 169 citations

Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine

2004 • 169 citations

Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth.

2002 • 165 citations

Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.

1992 • 165 citations

On the Role of Liver X Receptors in Lipid Accumulation in Adipocytes

2003 • 165 citations

Characterization of the Human PPARα Promoter: Identification of a Functional Nuclear Receptor Response Element

2002 • 164 citations

Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice

2002 • 163 citations

The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.

1991 • 161 citations

Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes

2002 • 160 citations

The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells

1999 • 159 citations

Expression of Peroxisome Proliferator-activated Receptor PPARδ Promotes Induction of PPARγ and Adipocyte Differentiation in 3T3C2 Fibroblasts

1999 • 158 citations

Glucose and Insulin Function through Two Distinct Transcription Factors to Stimulate Expression of Lipogenic Enzyme Genes in Liver

2001 • 154 citations

Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

2001 • 150 citations

Peroxisome Proliferator-activated Receptor α (PPARα) Influences Substrate Utilization for Hepatic Glucose Production

2002 • 150 citations

Peroxisome Proliferator-Activated Receptor (PPAR)-α Activation Prevents Diabetes in OLETF Rats

2003 • 150 citations

The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)

2002 • 149 citations

Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein

2004 • 146 citations

Targeted Elimination of Peroxisome Proliferator-Activated Receptor γ in β Cells Leads to Abnormalities in Islet Mass without Compromising Glucose Homeostasis

2003 • 145 citations

Mechanisms Governing the Expression of the Enzymes of Glutamine Metabolism—Glutaminase and Glutamine Synthetase

2001 • 142 citations

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements

2004 • 141 citations

Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

2002 • 140 citations

Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice

2001 • 140 citations

Cellular oscillators: rhythmic gene expression and metabolism

2005 • 139 citations

Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family

1993 • 138 citations

A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

2000 • 134 citations

Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosphorylation-dependent manner

1994 • 134 citations

GLUT4Gene Regulation and Manipulation

1999 • 133 citations

Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator

2002 • 131 citations

Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue.

1994 • 129 citations

Role of Foxa-2 in adipocyte metabolism and differentiation

2003 • 128 citations

Hepatocyte Nuclear Factor 1, a Transcription Factor at the Crossroads of Glucose Homeostasis

2000 • 121 citations

A genetic dissection of the retinoid signalling pathway in the mouse

1999 • 120 citations

Peroxisome proliferator-activated receptor δ activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes

2003 • 120 citations

Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice

1999 • 120 citations

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription

2001 • 117 citations

Regulation of insulin gene transcription

2000 • 117 citations

Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes

2004 • 115 citations

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

2005 • 114 citations

Tandem repeat of C/EBP binding sites mediates PPAR?2 gene transcription in glucocorticoid-induced adipocyte differentiation

2000 • 113 citations

Functional characterization of the L-type pyruvate kinase gene glucose response complex.

1993 • 113 citations

Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice

2004 • 106 citations

The Glucocorticoid-responsive Gene Cascade

1997 • 105 citations

A Phase I study of LGD1069 in adults with advanced cancer.

1999 • 104 citations

Analysis of protein dimerization and ligand binding of orphan receptor HNF4α

2000 • 104 citations

Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α)

2002 • 103 citations

SREBP-1c Mediates the Insulin-dependent Hepatic Glucokinase Expression

2004 • 102 citations

Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells.

2002 • 101 citations

Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells

1998 • 100 citations

Hepatocyte Nuclear Factor-4 Is a Novel Downstream Target of Insulin via FKHR as a Signal-regulated Transcriptional Inhibitor

2003 • 99 citations

PPARa activators improve insulin sensitivity and reduce adiposity

2000 • 96 citations

The Transcription Factor SREBP-1c Is Instrumental in the Development of औ-Cell Dysfunction

2003 • 91 citations

T<scp>HE</scp> R<scp>OLE OF</scp> C/EBP <scp>IN</scp> N<scp>UTRIENT AND</scp> H<scp>ORMONAL</scp> R<scp>EGULATION OF</scp> G<scp>ENE</scp> E<scp>XPRESSION</scp>

2001 • 91 citations

RXR Agonists Activate PPARα-Inducible Genes, Lower Triglycerides, and Raise HDL Levels In Vivo

1998 • 87 citations

Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis

2002 • 86 citations

A Thyroid Hormone Response Unit Formed between the Promoter and First Intron of the Carnitine Palmitoyltransferase-Iα Gene Mediates the Liver-specific Induction by Thyroid Hormone

2003 • 85 citations

A Novel Potent Antagonist of Peroxisome Proliferator-Activated Receptor γ Blocks Adipocyte Differentiation But Does Not Revert the Phenotype of Terminally Differentiated Adipocytes

2001 • 85 citations

Glucocorticoid Receptor, C/EBP, HNF3, and Protein Kinase A Coordinately Activate the Glucocorticoid Response Unit of the Carbamoylphosphate Synthetase I Gene

1998 • 84 citations

The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation

2004 • 84 citations

Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids

2001 • 83 citations

Mice Expressing the Human CYP7A1 Gene in the Mouse CYP7A1 Knock-out Background Lack Induction of CYP7A1 Expression by Cholesterol Feeding and Have Increased Hypercholesterolemia When Fed a High Fat Diet

2002 • 83 citations

Differences in the Molecular Mechanisms Involved in the Transcriptional Activation of the CHOP and Asparagine Synthetase Genes in Response to Amino Acid Deprivation or Activation of the Unfolded Protein Response

2002 • 80 citations

The Regulation of Uncoupling Protein-2 Gene Expression by ω-6 Polyunsaturated Fatty Acids in Human Skeletal Muscle Cells Involves Multiple Pathways, Including the Nuclear Receptor Peroxisome Proliferator-activated Receptor β

2001 • 79 citations

CCAAT/Enhancer-binding Protein-β Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene

2001 • 79 citations

Mice with a Deletion in the Gene for CCAAT/Enhancer-binding Protein β Have an Attenuated Response to cAMP and Impaired Carbohydrate Metabolism

2001 • 78 citations

CREB Binding Protein Recruitment to the Transcription Complex Requires Growth Factor–Dependent Phosphorylation of Its GF Box

2001 • 78 citations

Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

2001 • 74 citations

Conserved Transcriptional Regulatory Domains of the pdx-1 Gene

2004 • 73 citations

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer

2004 • 71 citations

Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids

2001 • 71 citations

Thyroid Hormone Regulates Carnitine Palmitoyltransferase Iα Gene Expression through Elements in the Promoter and First Intron

2000 • 70 citations

Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout Mice

1998 • 70 citations

Mechanism of Selective Retinoid X Receptor Agonist-Induced Hypothyroidism in the Rat

2002 • 70 citations

New insights into inhibitors of adipogenesis

2004 • 66 citations

Glutamine and Cell Signaling in Liver

2001 • 64 citations

WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog

2000 • 64 citations

Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation

2003 • 60 citations

Peroxisome proliferator-activated receptors β/δ: emerging roles for a previously neglected third family member

2003 • 58 citations

Genetic Manipulations of Fatty Acid Metabolism in β-Cells Are Associated With Dysregulated Insulin Secretion

2002 • 57 citations

Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice

2000 • 54 citations

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

2003 • 51 citations

Peroxisomal Proliferator-Activated Receptor α Deficiency Diminishes Insulin-Responsiveness of Gluconeogenic/Glycolytic/Pentose Gene Expression and Substrate Cycle Flux

2003 • 50 citations

Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding

2003 • 50 citations

Peroxisome proliferator-activated receptors β/δ: emerging roles for a previously neglected third family member

2003 • 49 citations

Ragaglitazar: The Pharmacokinetics, Pharmacodynamics, and Tolerability of a Novel Dual PPARα and γ Agonist in Healthy Subjects and Patients with Type 2 Diabetes

2003 • 48 citations

Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter

1997 • 45 citations

Upstream Stimulatory Factor Represses the Induction of Carnitine Palmitoyltransferase-Iऔ Expression by PGC-1

2003 • 44 citations

Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase

2000 • 44 citations

Two 5′-Regions Are Required for Nutritional and Insulin Regulation of the Fatty-acid Synthase Promoter in Transgenic Mice

2000 • 38 citations

Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane

2003 • 35 citations

A Distal Region Involving Hepatocyte Nuclear Factor 4α and CAAT/Enhancer Binding Protein Markedly Potentiates the Protein Kinase A Stimulation of the Glucose-6-Phosphatase Promoter

2004 • 35 citations

RXR activators molecular signalling: involvement of a PPARα‐dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart

2003 • 34 citations

Experimental Models of Transcription Factor-Associated Maturity-Onset Diabetes of the Young

2002 • 33 citations

Hepatic expression of CCAAT/enhancer binding protein α: hormonal and metabolic regulation in rats

1997 • 31 citations

A Silencer Element in the Regulatory Region of Glutamine Synthetase Controls Cell Type-specific Repression of Gene Induction by Glucocorticoids

1999 • 30 citations

CCAAT/enhancer-binding protein β is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes

2001 • 29 citations

Different regulation of the LXRα promoter activity by isoforms of CCAAT/enhancer-binding proteins

2002 • 27 citations

Selective stimulation of G-6-Pase catalytic subunit but not G-6-Ptransporter gene expression by glucagon in vivo and cAMP in situ

2004 • 26 citations

Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7α-hydroxylase mRNA levels

2003 • 25 citations

A Single Regulatory Module of the Carbamoylphosphate Synthetase I Gene Executes Its Hepatic Program of Expression

2000 • 24 citations

Molecular and genetic bases for maturity onset diabetes of youth

2000 • 24 citations

Elements in the Distal 5-Flanking Sequence and the First Intron Function Cooperatively to Regulate Glutamine Synthetase Transcription during Adipocyte Differentiation

1997 • 23 citations

Desperately Seeking…Something

2002 • 22 citations

The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene

2003 • 21 citations

Effect of Acidosis on the Properties of the Glutaminase mRNA pH-Response Element Binding Protein

2000 • 21 citations

Liver X receptors: Xcreting Xol to combat atherosclerosis

2002 • 14 citations

Selective RXR modulators for the treatment of type II diabetes.

2002 • 11 citations