Liver X receptors: Xcreting Xol to combat atherosclerosis

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

2001 • 1,134 citations

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

2001 • 1,062 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 • 913 citations

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors

2002 • 745 citations

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

2002 • 653 citations

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 • 643 citations

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

2000 • 543 citations

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

2000 • 540 citations

The role of PPAR-γ in macrophage differentiation and cholesterol uptake

2001 • 507 citations

Potent Inhibitory Effect of Troglitazone on Carotid Arterial Wall Thickness in Type 2 Diabetes

1998 • 463 citations

ABCA1: the gatekeeper for eliminating excess tissue cholesterol

2001 • 460 citations

Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages

2000 • 386 citations

Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene

2000 • 377 citations

Regulation of cholesterol 7α-hydroxylase gene ( CYP7A1 ) transcription by the liver orphan receptor (LXRα)

2001 • 372 citations

Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux

2002 • 370 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

2001 • 288 citations

Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ

2001 • 281 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 222 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 204 citations

Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1

2001 • 199 citations

Cross-Talk between Fatty Acid and Cholesterol Metabolism Mediated by Liver X Receptor-α

2000 • 187 citations

The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor

2001 • 140 citations

A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux

2002 • 120 citations

Potent Inhibitory Effect of Troglitazone on Carotid Arterial Wall Thickness in Type 2 Diabetes

1998 • 117 citations

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 • 108 citations

Cross-Talk between Fatty Acid and Cholesterol Metabolism Mediated by Liver X Receptor-

2000 • 52 citations

The Entero-Hepatic Nuclear Receptors Integrate Cholesterol, Lipid, and Bile Acid Homeostasis

2002 • 1 citations