Coordination of circadian timing in mammals

Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock

2002 • 3,319 citations

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity

2002 • 2,510 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

2000 • 1,523 citations

Extensive and divergent circadian gene expression in liver and heart

2002 • 1,498 citations

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

1995 • 1,437 citations

Molecular Analysis of Mammalian Circadian Rhythms

2001 • 1,428 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

A Novel Human Opsin in the Inner Retina

2000 • 1,236 citations

Time zones: a comparative genetics of circadian clocks

2001 • 1,142 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

2002 • 785 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

2002 • 701 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2

1999 • 668 citations

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

1999 • 613 citations

Regulation of Corepressor Function by Nuclear NADH

2002 • 595 citations

Melanopsin in cells of origin of the retinohypothalamic tract

2001 • 556 citations

NPAS2: An Analog of Clock Operative in the Mammalian Forebrain

2001 • 555 citations

The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei

2002 • 541 citations

Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

2001 • 533 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

2001 • 508 citations

Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators

2001 • 467 citations

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

2001 • 465 citations

Photoreceptive net in the mammalian retina

2002 • 458 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

2001 • 376 citations

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism

2001 • 374 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms

2000 • 343 citations

The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract

2002 • 332 citations

GABA Synchronizes Clock Cells within the Suprachiasmatic Circadian Clock

2000 • 331 citations

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

2002 • 328 citations

Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function

2000 • 297 citations

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

2002 • 296 citations

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

2002 • 282 citations

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

2000 • 268 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock

2002 • 263 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene

2001 • 251 citations

Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

2001 • 244 citations

Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock

2002 • 241 citations

Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro

2000 • 240 citations

Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker

2001 • 225 citations

SCN Efferents to Peripheral Tissues: Implications for Biological Rhythms

2001 • 192 citations

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

2002 • 179 citations

Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice

2000 • 166 citations

Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

1999 • 163 citations

Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

2002 • 157 citations

Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2

2002 • 149 citations

Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior

2001 • 147 citations

Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues

2000 • 143 citations

Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1

2002 • 143 citations

Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts

2001 • 131 citations

Keeping time with the human genome

2001 • 121 citations

Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice

2001 • 95 citations

Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees

2002 • 92 citations

Nuclear Export of Mammalian PERIOD Proteins

2001 • 89 citations

Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice

2001 • 70 citations

Photic induction of Period gene expression is reduced in Clock mutant mice

1999 • 57 citations