The peroxisome proliferator‐activated receptor α regulates amino acid metabolism

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

High density synthetic oligonucleotide arrays

1999 • 2,256 citations

Roles of PPARs in health and disease

2000 • 1,941 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

1999 • 1,589 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

1999 • 1,260 citations

A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

1999 • 931 citations

Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting

2000 • 422 citations

Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice

1997 • 419 citations

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

1995 • 410 citations

Biomedical Discovery with DNA Arrays

2000 • 362 citations

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

1995 • 342 citations

The Nuclear Receptors Peroxisome Proliferator-activated Receptor α and Rev-erbα Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates

1998 • 302 citations

Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans

1992 • 297 citations

Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes

1998 • 211 citations

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat.

1992 • 150 citations

Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-

1999 • 137 citations

Effect of Long-Chain Fatty Acids on Triglyceride Accumulation, Gluconeogenesis, and Ureagenesis in Bovine Hepatocytes

1998 • 137 citations

Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids

1987 • 126 citations

Down-Regulation of Cytochrome P450 2C Family Members and Positive Acute-Phase Response Gene Expression by Peroxisome Proliferator Chemicals

1998 • 102 citations

Transcriptional Suppression of the Transferrin Gene by Hypolipidemic Peroxisome Proliferators

1996 • 85 citations

Peroxisome Proliferator-activated Receptor α Inhibits Hepatic S14 Gene Transcription

1996 • 84 citations

Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor α-dependent pathway

1998 • 72 citations

Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout Mice

1998 • 70 citations

Coordinate Induction of the Urea Cycle Enzymes by Glucagon and Dexamethasone Is Accomplished by Three Different Mechanisms

1993 • 61 citations

Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription

2000 • 55 citations

Selective amplification via biotin- and restriction-mediated enrichment (SABRE), a novel selective amplification procedure for detection of differentially expressed mRNAs

1997 • 52 citations

Long‐chain fatty acids suppress the induction of urea cycle enzyme genes by glucocorticoid action

1996 • 46 citations

Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators

1999 • 42 citations

Suppressed Expression of the Urea Cycle Enzyme Genes in the Liver of Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice in Infancy and during Starvation in Adulthood

1997 • 26 citations

Effect of fatty acids on the disposition of ammonia.

1976 • 18 citations

Regulation of expression of genes for enzymes of the mammalian urea cycle in permanent cell-culture lines of hepatic and non-hepatic origin

1983 • 12 citations