Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Cellular and Molecular Aspects of Adipose Tissue Development

1992 • 671 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

1995 • 648 citations

Methods in Neurosciences

1992 • 622 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

1994 • 558 citations

Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.

1995 • 522 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

1992 • 493 citations

Differential activation of adipogenesis by multiple PPAR isoforms.

1996 • 470 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

1992 • 454 citations

CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

1994 • 433 citations

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa

1994 • 380 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

1995 • 368 citations

The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

1993 • 308 citations

The adipocyte: Storage depot or node on the energy information superhighway?

1995 • 298 citations

Obesity: adverse effects on health and longevity

1979 • 267 citations

Through thick and thin: Wasting, obesity, and TNFα

1993 • 223 citations

Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.

1980 • 217 citations

Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.

1996 • 208 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1992 • 162 citations

Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) α , β , and δ Genes in Fully-differentiated 3T3-L1 Adipocytes

1995 • 157 citations

Insulin binding and effects in isolated soleus muscle of lean and obese mice.

1978 • 145 citations

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

1994 • 143 citations

Cellular and Molecular Aspects of Adipose Tissue Development

1992 • 69 citations

Structure of the Mouse Peroxisome Proliferator Activated Receptor α Gene

1994 • 68 citations

Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle

1993 • 57 citations

Body Weight and Mortality among Women

1995 • 56 citations

Multiplex Solution Hybridization‐Ribonuclease Protection Assay for Quantitation of Different Ribonucleic Acid Transcripts from Snap‐Frozen Neuroendocrine Tissues of Individual Animals

1992 • 55 citations

Fatty Acid Activation of the Peroxisome Proliferator Activated Receptor, a Member of the Nuclear Receptor Gene Superfamily ,

1994 • 55 citations

Thiazolidinediones (AD-4833 and CS-045) Improve Hepatic Insulin Resistance in Streptozotocin-Induced Diabetic Rats.

1993 • 49 citations

Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function

1988 • 35 citations

Differentiation Dependent Biphasic Regulation of Adipsin Gene Expression by Insulin and Insulin-Like Growth Factor-1 in 3T3-F442A Adipocytes*

1990 • 22 citations