Glucocorticoid Receptor, C/EBP, HNF3, and Protein Kinase A Coordinately Activate the Glucocorticoid Response Unit of the Carbamoylphosphate Synthetase I Gene

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Impaired Energy Homeostasis in C/EBPα Knockout Mice

1995 • 925 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Functional specialization of different hepatocyte populations

1989 • 646 citations

Biochemical actions of hormones

1987 • 588 citations

Nitrogen metabolism and ornithine cycle function

1990 • 556 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Zonation of Parenchymal and Nonparenchymal Metabolism in Liver

1996 • 512 citations

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

1983 • 373 citations

Signal transduction and gene regulation: the nuclear response to cAMP

1994 • 369 citations

Fuels, Hormones, and Liver Metabolism at Term and during the Early Postnatal Period in the Rat

1973 • 351 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.

1993 • 306 citations

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

1996 • 289 citations

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

1991 • 270 citations

Regulation of Enzymes of Urea and Arginine Synthesis

1992 • 252 citations

Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor

1991 • 234 citations

A Nuclear Factor for Interleukin-6 Expression (NF-IL6) and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat α1-Acid Glycoprotein Gene via Direct Protein-Protein Interaction

1993 • 215 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-Dependent protein kinase

1991 • 192 citations

Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

1993 • 187 citations

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

1992 • 185 citations

Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions

1997 • 179 citations

Nucleosome displacement in transcription

1993 • 179 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice.

1990 • 155 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

The Developmental Formation of Enzymes in Rat Liver

1970 • 141 citations

Zonation of metabolism and gene expression in liver

1995 • 141 citations

Targeted Disruption of the Gene Encoding Hepatocyte Nuclear Factor 3γ Results in Reduced Transcription of Hepatocyte-Specific Genes

1998 • 137 citations

Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A

1991 • 132 citations

Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids

1987 • 126 citations

Hepatocyte Nuclear Factor 3 Determines the Amplitude of the Glucocorticoid Response of the Rat Tyrosine Aminotransferase Gene

1995 • 122 citations

Role of the CCAAT/Enhancer Binding Protein-α Transcription Factor in the Glucocorticoid Stimulation of p21 Gene Promoter Activity in Growth-arrested Rat Hepatoma Cells

1998 • 122 citations

Transcriptional regulation of genes for ornithine cycle enzymes

1995 • 108 citations

The Glucocorticoid-responsive Gene Cascade

1997 • 105 citations

Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.

1993 • 105 citations

Regulation of Messenger Ribonucleic Acid Levels for Five Urea Cycle Enzymes in Cultured Rat Hepatocytes. Requirements for Cyclic Adenosine Monophosphate, Glucocorticoids, and Ongoing Protein Synthesis

1988 • 98 citations

Permissive Effect of Dexamethasone on Glucagon Induction of Urea‐Cycle Enzymes in Perifused Primary Monolayer Cultures of Rat Hepatocytes

1979 • 95 citations

Induction of tyrosine aminotransferase synthesis in isolated liver cell suspensions. Absolute dependence of induction on glucocorticoids and glucagon or cyclic AMP.

1977 • 75 citations

Participation of Ets Transcription Factors in the Glucocorticoid Response of the Rat Tyrosine Aminotransferase Gene

1994 • 72 citations

Induction of the C/EBP Gene by Dexamethasone and Glucagon in Primary-Cultured Rat Hepatocytes

1996 • 70 citations

Glucocorticoids and Protein Kinase A Coordinately Modulate Transcription Factor Recruitment at a Glucocorticoid-Responsive Unit

1995 • 61 citations

The α-Isoform of the CCAAT/Enhancer-binding Protein Is Required for Mediating cAMP Responsiveness of the Phosphoenolpyruvate Carboxykinase Promoter in Hepatoma Cells

1996 • 60 citations

Developmental and hormonal regulation of carbamoyl-phosphate synthase gene expression in rat liver: Evidence for control mechanisms at different levels in the perinatal period

1986 • 54 citations

Hormonal Regulation of Glucokinase in Primary Cultures of Rat Hepatocytes

1979 • 51 citations

Towards Quantitative In Situ Hybridization

1997 • 50 citations

Cell‐specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice

1992 • 50 citations

Interaction of glucocorticoid hormones and cyclic nucleotides in induction of tyrosine aminotransferase in cultured hepatoma cells.

1977 • 49 citations

The Far-upstream Enhancer of the Carbamoyl-phosphate Synthetase I Gene Is Responsible for the Tissue Specificity and Hormone Inducibility of Its Expression

1995 • 45 citations

Individual Mouse α-Fetoprotein Enhancer Elements Exhibit Different Patterns of Tissue-Specific and Hepatic Position-Dependent Activities

1995 • 40 citations

Multihormonal control of enzyme clusters in rat liver ontogenesis II. Role of glucocorticosteroid and thyroid hormone and of glucagon and insulin

1981 • 36 citations

Hepatic glutaminase mRNA is confined to part of the urea cycle domain in the adult rodent liver lobule

1994 • 35 citations

Inducibility of carbamoylphosphate synthetase (ammonia) in cultures of embryonic hepatocytes: Ontogenesis of the responsiveness to hormones

1984 • 35 citations

The Spatio-temporal Control of the Expression of Glutamine Synthetase in the Liver Is Mediated by Its 5′-Enhancer

1995 • 33 citations

The Upstream Regulatory Region of the Carbamoyl-phosphate Synthetase I Gene Controls Its Tissue-specific, Developmental, and Hormonal Regulation in Vivo

1996 • 33 citations

Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis

1987 • 32 citations

Hepatic expression of CCAAT/enhancer binding protein α: hormonal and metabolic regulation in rats

1997 • 31 citations

Glucocorticoids are insufficient for neonatal gene induction in the liver

1998 • 29 citations

Development of the ornithine cycle in rat liver: Zonation of a metabolic pathway

1996 • 27 citations

Suppressed Expression of the Urea Cycle Enzyme Genes in the Liver of Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice in Infancy and during Starvation in Adulthood

1997 • 26 citations

Protein kinase A activation of glucocorticoid-mediated signaling in the developing retina.

1993 • 24 citations

Altered sodium current response to intracellular fatty acids in halothane-hypersensitive skeletal muscle

1996 • 23 citations

Isolation and Characterization of the Rat Gene for Carbamoylphosphate Synthetase I

1995 • 22 citations

Regulation of rat liver glucokinase activity in vivo: Predominant role of hepatic cyclic AMP and glucocorticoids

1979 • 17 citations

Isolation and Characterization of the Rat Gene for Carbamoylphosphate Synthetase I

1995 • 17 citations

cAMP activation of phosphoenolpyruvate carboxykinase transcription in renal LLC-PK1-F+ cells

1996 • 14 citations

Interaction between glucocorticoids, 8‐bromoadenosine 3′,5′‐monophosphate, and insulin in regulation of synthesis of carbamoyl‐phosphate synthetase I in Reuber hepatoma H‐35

1985 • 12 citations

Variable Responsiveness of Hormone-lnducible Hybrid Genes in Different Cell Lines

1988 • 11 citations

Role of cyclic AMP in the control of cell-specific gene expression

1993 • 7 citations