The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

1996 • 1,607 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

1993 • 1,516 citations

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1992 • 1,156 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

The insulin signalling system and the IRS proteins

1997 • 582 citations

Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins

1987 • 519 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus

1993 • 333 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

Mutations in the Insulin Receptor Gene

1992 • 294 citations

Mapping Genes in Diabetes: Genetic Epidemiological Perspective

1990 • 290 citations

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.

1996 • 232 citations

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1

1995 • 216 citations

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

1995 • 146 citations

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.

1994 • 145 citations

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations

1996 • 103 citations

Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.

1994 • 101 citations

Glucose-Induced Insulin Receptor Tyrosine Phosphorylation in Insulin-Secreting β-Cells

1995 • 97 citations

Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

1990 • 88 citations

Glucose‐ and insulin‐induced phosphorylation of the insulin receptor and its primary substrates IRS‐1 and IRS‐2 in rat pancreatic islets

1995 • 79 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms

1996 • 65 citations

Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling

1997 • 57 citations

Deleted Work

1955 • 0 citations