Glutamine and Cancer

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

1996 • 824 citations

Glutamine and Cancer

1993 • 285 citations

Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis

1999 • 250 citations

Recent Molecular Advances in Mammalian Glutamine Transport

2001 • 239 citations

Glutamine, as a Precursor of Glutathione, and Oxidative Stress

1999 • 217 citations

Relevance of glutamine metabolism to tumor cell growth

1992 • 184 citations

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

1999 • 183 citations

A Quantitative Approach to Metabolic Control

1985 • 140 citations

Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

2000 • 130 citations

Glutamine, cancer, and its therapy

1996 • 124 citations

Some aspects of nitrogen and energy metabolism in cancerous subjects: a review.

1951 • 115 citations

High levels of transglutaminase expression in doxorubicin‐resistant human breast carcinoma cells

1994 • 109 citations

Glutamine Enhances Selectivity of Chemotherapy Through Changes in Glutathione Metabolism

1995 • 108 citations

Reduction of chemotherapy-induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer

1999 • 103 citations

Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor cells.

1984 • 90 citations

Therapeutic considerations of L-glutamine: a review of the literature.

1999 • 86 citations

Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase

2000 • 85 citations

Glutamine Enhances Immunoregulation of Tumor Growth

1994 • 82 citations

On the Multiform Relationships between the Tumor

1979 • 76 citations

Glutamine supplementation in cancer patients receiving chemotherapy: A double-blind randomized study

1997 • 72 citations

The Effects of Glutamine-enriched Total Parenteral Nutrition on Tumor Growth and Host Tissues

1992 • 67 citations

Glutamine Protects against Doxorubicin-Induced Cardiotoxicity

1999 • 65 citations

Glutaminolysis and glycolysis interactions in proliferant cells

1990 • 63 citations

Tissue transglutaminase expression in human breast cancer.

1996 • 63 citations

The Human Prostate-Specific Transglutaminase Gene (TGM4): Genomic Organization, Tissue-Specific Expression, and Promoter Characterization

1998 • 61 citations

Reduction of transglutaminase 2 expression is associated with an induction of drug sensitivity in the PC-14 human lung cancer cell line

1999 • 60 citations

Aspects of amino acid and protein metabolism in cancer-bearing states

1985 • 58 citations

l-glutamine: a major substrate for tumor cells in vivo?

1987 • 55 citations

Phosphate‐activated glutaminase expression during tumor development

1994 • 54 citations

Conditions for activity of glutaminase in kidney mitochondria

1970 • 53 citations

Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells.

1988 • 51 citations

A Comparative Study of Glutaminase Isozymes in Rat Tissues

1976 • 47 citations

The bhopalator: a molecular model of the living cell based on the concepts of conformons and dissipative structures

1985 • 47 citations

Effect of Glutamine Supplementation on Protein Metabolism and Glutathione in Tumor‐Bearing Rats

1995 • 44 citations

Prevention of chronic radiation enteropathy by dietary glutamine

1994 • 43 citations

Human prostate-specific transglutaminase gene: promoter cloning, tissue-specific expression, and down-regulation in metastatic prostate cancer

1999 • 33 citations

Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells

1988 • 33 citations

Regulation of glutamine synthetase in human breast carcinoma cells and experimental tumors

1997 • 33 citations

Submitochondrial localization and membrane topography of Ehrlich ascitic tumour cell glutaminase

1997 • 31 citations

Glutamine transport by vesicles isolated from tumour-cell mitochondrial inner membrane

1995 • 31 citations

Glycolysis and glutaminolysis in perifused ehrlich ascites tumour cells

1989 • 26 citations

THE UTILITY OF TISSUE TRANSGLUTAMINASE AS A MARKER OF APOPTOSIS DURING TREATMENT AND PROGRESSION OF PROSTATE CANCER

1999 • 26 citations

Normalization of Tumor-Induced Increases in Hepatic Amino Acid Transport After Surgical Resection

1995 • 18 citations

Mouse liver free amino acids during the development of Ehrlich ascites tumour

1991 • 17 citations

Tumor Glutaminase Purification

1995 • 14 citations

l-Glutamine transport in native vesicles isolated from Ehrlich ascites tumor cell membranes

1991 • 14 citations

Effect of palmitate, acetate and glucose on glutamine metabolism in Ehrlich ascites tumor cells

1988 • 13 citations

Involvement of essential cysteine and histidine residues in the activity of isolated glutaminase from tumour cells

1998 • 12 citations

Early differential expression of two glutaminase mRNAs in mouse spleen after tumor implantation

1998 • 10 citations

Inorganic phosphate and energy charge compartmentation in Ehrlich ascites tumour cells in the presence of glucose and/or glutamine.

1988 • 7 citations

Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.

2000 • 7 citations

Evidence of an Intracellular Dissipative Structure

1988 • 5 citations

Mobilization of glutamine and asparagine in mouse kidney during Ehrlich cell carcinoma development

1996 • 4 citations