Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

C/EBPα induces adipogenesis through PPARγ: a unified pathway

2002 • 1,345 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus

1999 • 697 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression

2002 • 603 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

Fatty acids, lipotoxicity and insulin secretion

1999 • 563 citations

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

2001 • 523 citations

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

1997 • 438 citations

PPARγ<scp>AND</scp>G<scp>LUCOSE</scp>H<scp>OMEOSTASIS</scp>

2002 • 402 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux

2002 • 370 citations

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

2000 • 367 citations

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice

2002 • 359 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

PPARs: transcriptional effectors of fatty acids and their derivatives

2002 • 306 citations

Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-α) and PPAR-γ Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-γ-Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice**This work was supported by grants from the Research Service of the Department of Veterans Affairs (to C.G. and K.R.F.), NIH Grant DK-49448 (to C.G.), and Merck Research Laboratories (to L.H.T. and K.N.).

2000 • 289 citations

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

2002 • 273 citations

Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.

1996 • 259 citations

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

2002 • 224 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 222 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 204 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose- predominant expression and induction early in adipocyte differentiation

1994 • 203 citations

Insulin Resistance and Its Treatment by Thiazolidinediones

2001 • 184 citations

Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones

2001 • 173 citations

PPARs: Transcription Factors Controlling Lipid and Lipoprotein Metabolism

2002 • 172 citations

Isolation and subfractionation on ficoll gradients of adult rat hepatocytes. Size, morphology, and biochemical characteristics of cell fractions.

1975 • 166 citations

Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver

2001 • 160 citations

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

1994 • 157 citations

SREBP-1 Mediates Activation of the Low Density Lipoprotein Receptor Promoter by Insulin and Insulin-like Growth Factor-I

1996 • 157 citations

Human adipose tissue lipoprotein lipase: changes with feeding and relation to postheparin plasma enzyme

1985 • 138 citations

Hepatic lipase

2002 • 135 citations

Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.

1999 • 133 citations

Peroxisome proliferator-activated receptor is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis

2000 • 129 citations

PPAR∞ AND GLUCOSE HOMEOSTASIS

2002 • 128 citations

Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor γ

2001 • 115 citations

Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus.

2001 • 115 citations

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?

2001 • 64 citations

Unique Ability of Troglitazone to Up-Regulate Peroxisome Proliferator-Activated Receptor-γ Expression in Hepatocytes

2002 • 63 citations

Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR- ) and PPAR- Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR- -Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice

2000 • 62 citations

Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice

2000 • 54 citations

Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

2002 • 44 citations

PPARγ agonists in type 2 diabetes: how far have we come in ‘preventing the inevitable’? A review of the metabolic effects of rosiglitazone

2001 • 39 citations